{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:56:42Z","timestamp":1778511402349,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To establish the optimal strategy for haploidentical hematopoietic stem cell transplantation (HSCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective study on haploidentical HSCT using low\u2010dose alemtuzumab. Alemtuzumab was added at 0.25\u00a0mg\/kg for 2\u00a0days. The primary outcome measure was the survival rate with the engraftment of donor cells and without grade III\u2010IV acute graft\u2010vs\u2010host disease (GVHD) at 60\u00a0days after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen adult patients with advanced hematological disease were enrolled. The primary outcome measure was achieved in 86% of the patients. Six patients experienced relapse\/progression. Non\u2010relapse death was observed in three patients, and all of them had a history of previous allogeneic HSCT. Overall survival and progression\u2010free survival rates at 1\u00a0year were 51% and 43%, respectively. Four patients were suspected to have herpes simplex virus infection and three had aseptic meningitis under the use of acyclovir at 200\u00a0mg. There were no deaths due to viral infection. Compared to those who underwent haploidentical HSCT using thymoglobulin, patients with alemtuzumab showed a slower recovery of CD8<jats:sup>+<\/jats:sup> T\u2010cells and lower incidences of GVHD and EB virus reactivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Haploidentical HSCT using low\u2010dose alemtuzumab can be performed safely. We need to overcome the high relapse\/progression rate in non\u2010remission patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13204","type":"journal-article","created":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T16:48:56Z","timestamp":1545497336000},"page":"256-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Haploidentical transplantation using low\u2010dose alemtuzumab: Comparison with haploidentical transplantation using low\u2010dose thymoglobulin"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-3395","authenticated-orcid":false,"given":"Shinichi","family":"Kako","sequence":"first","affiliation":[{"name":"Division of Hematology, Saitama Medical Center Jichi Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Gomyo","sequence":"additional","affiliation":[{"name":"Division of Hematology, 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