{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:36:59Z","timestamp":1790869019516,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>T\u2010cell<jats:bold>\u2013<\/jats:bold>replete haploidentical stem cell transplantation (Haplo\u2010SCT) with post\u2010transplant cyclophosphamide (PT\u2010Cy) is at high risk of invasive fungal infections (IFI), and anti\u2010mold\u2013active drug is required for primary antifungal prophylaxis (PAP) according to international guidelines. No data are available on the efficacy of caspofungin as PAP in this setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we report our retrospective experience with 103 consecutive patients treated with caspofungin as PAP after Haplo\u2010SCT. Caspofungin was administered only during the pre\u2010engraftment phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hundred\u2010day cumulative incidence of proven\u2010probable IFI (PP\u2010IFI) was 8.7% and median day of onset was 19 post\u2010SCT. No patient died of PP\u2010IFI, and overall survival (OS) and non\u2010relapse mortality (NRM) hazard ratio (HR) for patients experiencing IFI were 1.02 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.9) and 0.7 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.7), respectively. Three\u2010year overall survival (OS) and 1\u2010year non\u2010relapse mortality (NRM) were 55% and 19%, respectively. By univariate analysis, duration of neutropenic phase and partial remission pre\u2010transplant disease status were associated with increased incidence of IFI, but were not confirmed by multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, PAP with caspofungin is an effective strategy for preventing IFI in the context of Haplo\u2010SCT with PT\u2010Cy. Further efforts are required in order to identify more potent strategies able to avoid the occurrence of breakthrough infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13214","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T16:57:14Z","timestamp":1548349034000},"page":"357-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Caspofungin for primary antifungal prophylaxis after T\u2010cell\u2013replete haploidentical stem cell transplantation with post\u2010transplant cyclophosphamide"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6528-9296","authenticated-orcid":false,"given":"Jacopo","family":"Mariotti","sequence":"first","affiliation":[{"name":"Bone Marrow Unit, Humanitas Cancer Center Istituto Clinico Humanitas Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"De 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