{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:42:00Z","timestamp":1780508520307,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Post\u2010transplant lymphoproliferative disorder (PTLD) is an infrequent complication of allogeneic stem cell transplant (allo\u2010SCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To estimate the frequency and management of PTLD in Spain and to identify prognostic factors influencing outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicenter, retrospective analysis of allo\u2010SCT performed in 14 transplant units over a 15\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>102 PTLD were diagnosed among 12\u00a0641 allo\u2010SCT, leading to an estimated frequency of 0.8%. PTLD was diagnosed at a median of 106\u00a0days after SCT. Eighty\u2010seven cases (85%) were diagnosed between 2007 and 2013. At diagnosis, 22% and 17% of the patients had gastrointestinal tract and CNS involvement. Eighty\u2010seven (85%) received rituximab treatment, alone or in combination with immunosuppression reduction, with an ORR of 50.6%. With a median follow\u2010up for survivors of 58\u00a0months, the 2\u2010year overall survival (OS) was 33% and the PTLD\u2010related mortality 45%. Age\u00a0\u2265\u00a040\u00a0years, malignant underlying disease, non\u2010response to rituximab, and severe thrombocytopenia or lymphocytopenia at PTLD diagnosis were associated with worse overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Only a small proportion of allografted patients were diagnosed a PTLD. Its clinical course was highly aggressive, and prognosis poor, especially in those failing rituximab. The prognostic impact found of the platelet, and lymphocyte count at diagnosis requires further confirmation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13226","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T07:14:41Z","timestamp":1551683681000},"page":"465-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Frequency, characteristics, and outcome of PTLD after allo\u2010SCT: A multicenter study from the Spanish group of blood and marrow transplantation (GETH)"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2994-9055","authenticated-orcid":false,"given":"Irene","family":"Garc\u00eda\u2010Cadenas","sequence":"first","affiliation":[{"name":"Department of Hematology of the: Hospital de la Santa Creu I Sant Pau, Biomedical Research Institute (IIB Sant\u2010Pau) Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrecia","family":"Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"HU. 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