{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:32:37Z","timestamp":1769074357767,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T00:00:00Z","timestamp":1554595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["DP08160"],"award-info":[{"award-number":["DP08160"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Acute promyelocytic leukemia (APL) is highly curable. To achieve high cure rates, targeted therapy with retinoic acid (ATRA) must be started promptly at time of suspected diagnosis. Early death rates (EDRs, \u226430\u00a0days from diagnosis) differ markedly in patients treated on clinical trials compared to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives and methods<\/jats:title><jats:p>We used the comprehensive Danish National Acute Leukemia Registry (DNLR) to investigate the incidence, treatment, EDR, and long\u2010term clinical outcome in APL between 2000 and 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two of 41 deaths occurring in 122 APL patients were EDs which were primarily caused by intracranial hemorrhage, disseminated intravascular coagulation (DIC), sepsis, and multiorgan failure. The overall EDR was 18.0%, whereas clinical trial participants had an EDR of 6.7%. Fifteen patients recruited to the NCRI AML17 APL trial from 2010 to 2013 were younger and had decreased mortality (HR 0.18, CI 0.04\u20100.86, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) compared to contemporarily treated patients (n\u00a0=\u00a015) not recruited to a clinical trial. Performance status, leukemia origin, and Sanz\u2010score were independent prognostic variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The very low EDR for on\u2010trial patients is not observed in the general cohort of APL patients. Diagnostic awareness emerges as the greatest clinical challenge in management of APL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13229","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:03:08Z","timestamp":1553040188000},"page":"479-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Addressing the room for improvement in management of acute promyelocytic leukemia"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-118X","authenticated-orcid":false,"given":"Jan M.","family":"N\u00f8rgaard","sequence":"first","affiliation":[{"name":"Department of Hematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone S.","family":"Friis","sequence":"additional","affiliation":[{"name":"Department of Hematology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen S.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital Aarhus Denmark"},{"name":"Horsens Regional Hospital Horsens Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne T.","family":"Severinsen","sequence":"additional","affiliation":[{"name":"Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingolf","family":"M\u00f8lle","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus W.","family":"Marcher","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Hematology Roskilde Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Schoellkopf","sequence":"additional","affiliation":[{"name":"Department of Hematology Herlev Hospital Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ove J.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte S.","family":"Preiss","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette K.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eigil","family":"Kjeldsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno C.","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene S.G.","family":"\u00d8stg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Danish Acute Leukemia Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.2.567.567"},{"issue":"9","key":"e_1_2_8_3_1","first-page":"3015","article-title":"A modified AIDA protocol with anthracycline\u2010based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML\/RARalpha\u2010positive acute promyelocytic leukemia. 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