{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:04:42Z","timestamp":1768989882927,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Approximately 10% of Philadelphia (Ph)\u2010negative myeloproliferative neoplasms (NPM) are diagnosed at young adulthood. We aim to define the features of this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter retrospective study, including patients 18\u201045\u00a0years of age, diagnosed with Ph\u2010negative MPN between 1985 and 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred nine patients were included, 37 with polycythemia vera (34%), 54 with essential thrombocytosis (50%), 15 with primary myelofibrosis (PMF) (14%), and 3 with MPN unclassifiable (3%). Median age was 33\u00a0years and 62 (57%) were females. During a median follow\u2010up of 8\u00a0years, 39 patients (37%) had at least one thrombotic event. 30\/39 of events were venous (77%), 23\/30 of which were splanchnic (77%). In 14\/39 (36%), thrombosis preceded MPN diagnosis. In a multivariable analysis, only splenomegaly predicted for thrombosis (HR 5.6, CI: 1.4\u201022). The 10\u2010year risk for secondary myelofibrosis was similar for ET and PV (0.13 vs 0.19, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.51). The 10\u2010year risk for leukemic transformation or mortality was significantly higher for PMF (0.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risks of mortality and of progression to MF\/leukemia in young adults are similar to older population. Thrombotic events are frequently a presenting sign with a high incidence of venous, in particular splanchnic, events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13232","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T06:30:01Z","timestamp":1554273001000},"page":"504-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Characteristics and outcomes of young adults with Philadelphia\u2010negative myeloproliferative neoplasms"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3290-7291","authenticated-orcid":false,"given":"Merav","family":"Barzilai","sequence":"first","affiliation":[{"name":"Division of Hematology Sourasky Medical Center Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv 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