{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:42:54Z","timestamp":1785285774905,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the role of N\u2010terminal pro\u2010brain\u2010type natriuretic peptide (NT\u2010proBNP) and a cardiovascular (CV) risk score named FRESCO for predicting anthracycline\u2010induced cardiotoxicity (AIC) in diffuse large B\u2010cell lymphoma (DLBCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 130 consecutive DLBCL patients treated in first\u2010line with anthracycline\u2010containing immunochemotherapy. Competitive risk between NT\u2010proBNP, FRESCO, and time to AIC was considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cumulative incidence of AIC was 12.2% and 17.5% at 1 and 5\u00a0years, respectively. Median time to development cardiotoxicity was 6.4\u00a0months, with half of the cases showing heart failure and the other half silent AIC. Both NT\u2010proBNP levels and FRESCO score were independently associated with higher risk of AIC (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03, respectively). Patients with NT\u2010proBNP \u2265600\u00a0pg\/mL or those with FRESCO \u22654.5% had 3.97 or 2.54 times higher risk of AIC than those with lower values (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.048, respectively). According to the previous cutoffs, three groups of patients with a significantly different risk of AIC could be identified (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Doxorubicin\u2010containing chemotherapy is associated with increased risk of silent and overt AIC. Baseline NT\u2010proBNP levels and FRESCO CV risk score are accurate predictors of AIC and can identify groups of patients at different risk, in which personalized cardiologic evaluation should be offered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13234","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T23:45:29Z","timestamp":1555026329000},"page":"509-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Anthracycline\u2010induced cardiotoxicity in diffuse large B\u2010cell lymphoma: NT\u2010proBNP and cardiovascular score for risk stratification"],"prefix":"10.1111","volume":"102","author":[{"given":"Mariana Paola","family":"Ferraro","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital del Mar Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Clinical Hematology Research Group Hospital 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