{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:03:45Z","timestamp":1747184625120,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K15368","16K19203","17K09943"],"award-info":[{"award-number":["15K15368","16K19203","17K09943"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Prefibrotic\/early primary myelofibrosis (pre\u2010PMF) and essential thrombocythemia (ET) exhibited different features of bone marrow; however, this is not always easy to judge objectively, making pathologists\u2019 distinction often suboptimal. In the WHO 2008 criteria, pre\u2010PMF was not defined as a subgroup of PMF; therefore, affected patients were at a higher risk of misdiagnosis with ET. In this study, we examined the prevalence of pre\u2010PMF patients among those previously diagnosed with ET in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We reviewed bone marrow specimens and clinical and molecular parameters of patients who were previously diagnosed with ET by the WHO 2008 criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 107 ET patients, 13 patients were redefined as having pre\u2010PMF. Pre\u2010PMF patients exhibited a higher frequency of <jats:italic>MPL<\/jats:italic> mutation and increased platelet counts compared to true ET patients. Molecular analysis revealed the frequencies of high\u2010risk molecular mutations, such as <jats:italic>ASXL1<\/jats:italic>, <jats:italic>EZH2<\/jats:italic>, and <jats:italic>SRSF2<\/jats:italic>, were significantly increased in pre\u2010PMF patients than those in true ET patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results demonstrated the value of reexamining clinical records for patients diagnosed with ET by the WHO 2008 criteria and emphasized that adequate examinations of patients\u2019 bone marrow are crucial for an accurate diagnosis of pre\u2010PMF and ET.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13236","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T14:56:07Z","timestamp":1555080967000},"page":"516-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical and molecular features of patients with prefibrotic primary 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