{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:47:56Z","timestamp":1790740076387,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Angioimmunoblastic T\u2010cell lymphoma (AITL) is frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require particular management is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Angioimmunoblastic T\u2010cell lymphoma patients from the multicentric database of the Lymphoma Study Association presenting with AIC during disease course were included and matched to AITL patients without AIC (1\/5 ratio).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At diagnosis, AIC patients (n\u00a0=\u00a028) had more spleen and bone marrow involvement (54% vs 19% and 71% vs 34%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Epstein\u2010Barr virus replication (89% vs 39%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), gamma globulin titers (median 23 vs 15\u00a0g\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), and proliferating B cells and plasmablasts in biopsies, as compared to control patients (n\u00a0=\u00a0136). The 28 AIC patients had 41 episodes of AIC, diagnosed concomitantly with AITL in 23 (82%) cases. After a median follow\u2010up of 24\u00a0months (range 3\u2010155), 10 patients relapsed, all associated with AITL relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results provide new insight into AIC associated with AITL by highlighting the significant interplay between AITL and B\u2010cell activation leading to subsequent autoimmunity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13239","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T15:19:44Z","timestamp":1555341584000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Clinical spectrum, evolution, and management of autoimmune cytopenias associated with angioimmunoblastic T\u2010cell 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