{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:45:03Z","timestamp":1761965103963,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n Mutua Madrile\u00f1a","doi-asserted-by":"publisher","award":["08\/FMMA","PI13\/2729","PI16\/0940","PI17\/01246"],"award-info":[{"award-number":["08\/FMMA","PI13\/2729","PI16\/0940","PI17\/01246"]}],"id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Increased levels of Wilms\u2019 tumor (<jats:italic>WT1<\/jats:italic>) mRNA have been used to establish risk categories in patients with acute myeloid leukemia (AML). Raised values of <jats:italic>WT1<\/jats:italic> have been associated with progression in myelodysplastic syndrome (MDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the available bone marrow (BM) samples from 115 patients with myeloid neoplasms obtained before and during treatment with 5\u2010azacytidine. A threshold of 100 copies in BM was used to define risk groups: group 1: patients with <jats:italic>WT1<\/jats:italic> levels always below\u00a0&lt;\u00a0100 copies; group 2: cases with initial <jats:italic>WT1<\/jats:italic> levels greater than 100 copies but with a conversion to sustained levels below 100; and group 3: cases with follow\u2010up <jats:italic>WT1<\/jats:italic> levels greater than 100.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients were included in group 1, 17 in group 2, and 78 in group 3. Survival analysis showed statistically significant differences in terms of OS between groups (p: 0.016). Patients in group 2 showed the best 5\u2010year overall survival (OS). In multivariate analysis, only the cytogenetic risk category and receiving an allogeneic hematopoietic stem cell transplantation (HCT) independently predicted the survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Further studies are needed to assess whether BM <jats:italic>WT1<\/jats:italic> levels could be useful to predict the survival of patients with myeloid neoplasms treated with 5\u2010azacytidine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13275","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T19:54:10Z","timestamp":1560887650000},"page":"208-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Bone marrow WT1 levels in patients with myeloid neoplasms treated with 5\u2010azacytidine: Identification of responding patients"],"prefix":"10.1111","volume":"103","author":[{"given":"Marta","family":"Santaliestra","sequence":"first","affiliation":[{"name":"Hematology Department, Hospital de la Santa Creu I Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Garrido","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Santa Creu I Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"IIB Sant Pau and Josep Carreras Leukemia Foundation Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maite","family":"Carricondo","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Santa Creu I Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bussaglia","sequence":"additional","affiliation":[{"name":"Hematology 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