{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:51:48Z","timestamp":1786971108834,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T00:00:00Z","timestamp":1562457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>At our center, patients with multiple myeloma (MM) were treated upfront with bortezomib, cyclophosphamide, and dexamethasone (VCD) until cyclophosphamide was replaced with lenalidomide in the combination (VRD). These treatments have never been compared head\u2010to\u2010head in large real\u2010life patient material.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective analysis of patients treated with VRD and VCD in the first line, both with and without subsequent high\u2010dose treatment (HDT) and autologous stem cell transplantation. A total of 681 patients were included, 117 receiving VRD (71 with, 46 without HDT) and 564 receiving VCD (351 with, 213 without HDT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall response rate (\u2265partial response) was higher with VRD compared to VCD in the entire VRD group (98% vs 88%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and in the non\u2010HDT group (98% vs 79%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Progression\u2010free survival (PFS) at 18\u00a0months was longer with VRD compared to VCD in the entire VRD group, the non\u2010HDT group and the HDT group (88% vs 63%, 82% vs 32% and 91% vs 73%, respectively). Overall survival at 18\u00a0months was better for VRD\u2010treated patients in the entire VRD group (95% vs 89%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Upfront VRD gives better responses and longer PFS compared to VCD in MM patients with or without subsequent HDT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13280","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T07:29:50Z","timestamp":1561361390000},"page":"247-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Upfront bortezomib, lenalidomide, and dexamethasone compared to bortezomib, cyclophosphamide, and dexamethasone in multiple myeloma"],"prefix":"10.1111","volume":"103","author":[{"given":"Katarina","family":"Uttervall","sequence":"first","affiliation":[{"name":"Department of Medicine Karolinska Institutet Stockholm 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