{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:47:17Z","timestamp":1781196437919,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical outcome of hematopoietic stem cell transplantation (HSCT) in those with severe beta\u2010thalassemia (\u03b2\u2010TM) is closely related to post\u2010transplantation immune reconstitution (IR). However, the data on the IR in these settings are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective analysis of the clinical outcome and IR in 47 children with severe \u03b2\u2010TM who underwent in vivo T\u2010cell depletion myeloablative conditioning and matched sibling donor HSCT was performed. Immune reconstitution, including immune cell subset counts, as well as the generation of new T and B cells assays after HSCT, was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first year after HSCT, bacterial infections and cytomegalovirus (CMV) reactivation were observed in 70.2% and 36.2% of the patients, respectively. In the same period, poor CD4<jats:sup>+<\/jats:sup> T\u2010cell recovery was observed. The B cells recovered within 6\u00a0months. Natural killer (NK) cells recovered as early as 1\u00a0month, but their function was defective. Cord blood and bone marrow (CB\u00a0+\u00a0BM) group had slower T\u2010cell recovery, and higher B cells and NK cells in comparison with peripheral blood and bone marrow (PB\u00a0+\u00a0BM) group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The high incidence of infection within 1\u00a0year after\u00a0in vivo T\u2010cell depletion myeloablative conditioning HSCT in severe \u03b2\u2010TM was consistent with poor IR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13289","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T14:53:40Z","timestamp":1562338420000},"page":"342-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Immune recovery after in vivo T\u2010cell depletion myeloablative conditioning hematopoietic stem cell transplantation in severe beta\u2010thalassemia 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