{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T03:58:39Z","timestamp":1752983919011,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Causality between hepatitis B virus (HBV) infection and diffuse large B\u2010cell lymphoma (DLBCL) was reported in various studies. However, the implication of different virological serum markers of HBV infection in patients with both HBV infection and DLBCL is not fully understood. The aim of this study was to investigate the impact of HBV markers on overall survival (OS) and progression\u2010free survival (PFS) in patients with both HBV infection and DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, patients (n\u00a0=\u00a040) diagnosed with both HBV infection and DLBCL were identified between 2000 and 2017. Six patients with hepatitis C virus (HCV) and\/or human immunodeficiency virus (HIV) co\u2010infection were excluded from this study. We retrospectively analyzed patients\u2019 demographic characteristics, treatment, and the prognostic impact of different HBV markers at first diagnosis of DLBCL (HBsAg, anti\u2010HBs, HBeAg, anti\u2010HBe, and HBV\u2010DNA) on OS and PFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of patients (n\u00a0=\u00a021, 62%) had advanced disease stage (III\/IV) at diagnosis. In the first\u2010line therapy, 24 patients (70%) were treated with R\u2010CHOP regimen (rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisolone). HBeAg positive patients had a trend toward inferior OS and PFS compared with HBeAg negative patients. Anti\u2010HBe positive patients had a statistically significant better OS and PFS compared with anti\u2010HBe negative group (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). Viremia with HBV\u2010DNA\u00a0\u2265\u00a02\u00a0\u00d7\u00a010<jats:sup>7<\/jats:sup> IU\/L had a significant negative impact on OS and PFS (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High activity of viral replication is associated with a poor survival outcome of patients with both HBV infection and DLBCL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13300","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T01:13:15Z","timestamp":1563930795000},"page":"410-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of virological serum markers in patients with both hepatitis B virus infection and diffuse large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-0919","authenticated-orcid":false,"given":"Xiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine V, Heidelberg University Hospital University of Heidelberg Heidelberg Germany"},{"name":"Department of Internal Medicine II, W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9482-2870","authenticated-orcid":false,"given":"Patrick","family":"Wuchter","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim Heidelberg University German Red Cross Blood Service Baden\u2010W\u00fcrttemberg \u2010 Hessen Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlinde","family":"Egerer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V, Heidelberg University Hospital University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Kriegsmann","sequence":"additional","affiliation":[{"name":"Insititue of Pathology, Heidelberg University Hospital University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiste","family":"Mataityte","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Koelsche","sequence":"additional","affiliation":[{"name":"Insititue of Pathology, Heidelberg University Hospital University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Witzens\u2010Harig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V, Heidelberg University Hospital University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-1491","authenticated-orcid":false,"given":"Katharina","family":"Kriegsmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V, Heidelberg University Hospital University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.190353"},{"issue":"6","key":"e_1_2_6_3_1","first-page":"9937","article-title":"High prevalence of hepatitis B virus infection in primary central nervous system 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