{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:41:28Z","timestamp":1780411288049,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The primary objective was to assess the effect of central nervous system involvement in acute myeloid leukemia (CNS\u2010AML) on outcomes after allogeneic hematopoietic stem cell transplant (allo\u2010HCT). The secondary objective was to assess the utility of pretransplant cerebrospinal fluid (CSF) assessment in AML.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed survival outcomes in 338 adult AML patients (with and without CNS\u2010AML) after allo\u2010HCT. CNS involvement was defined as clinical, pathological, or radiological evidence of CNS involvement any time after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up in surviving patients was 23.7\u00a0months. Twenty\u2010five patients (7.4%) had prior history of CNS disease, with normal CSF pretransplant. Three patients had CSF blasts detected for the first time at pretransplant evaluation (0.88%). The 2\u2010year OS and RFS in groups with and without CNS involvement were not significantly different. Patients with CNS\u2010AML had significantly higher 1\u2010year cumulative incidence of relapse (29.7% vs 16.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048). Age more than 65\u00a0years and absence of marrow remission at transplant were significant adverse factors for survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CNS\u2010AML is not an independent risk factor for survival after allo\u2010HCT, but can be associated with higher relapse rates. Pretransplant CSF assessment has low yield in detecting new CNS disease pretransplant in AML.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13314","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T12:43:08Z","timestamp":1565959388000},"page":"483-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of central nervous system involvement in AML on outcomes after allotransplant and utility of pretransplant cerebrospinal fluid assessment"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-8306","authenticated-orcid":false,"given":"Shruti","family":"Prem","sequence":"first","affiliation":[{"name":"Princess Margaret Cancer Centre University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshetu G.","family":"Atenafu","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre 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