{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:01:51Z","timestamp":1754193711785,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and objectives<\/jats:title><jats:p>The most common mutation within the spectrum of myeloproliferative neoplasms (MPNs) is a mutation in Janus kinase 2 gene (<jats:italic>JAK2V617F<\/jats:italic>). It has been observed that, during a course of disease, transformation from <jats:italic>JAK2<\/jats:italic>\u2010mutated essential thrombocythemia (ET) to overt polycythemia vera (PV) can occur. Primary objective of this study was to show the incidence of mentioned phenomenon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we analyzed data of 136 patients diagnosed with <jats:italic>JAK2<\/jats:italic>\u2010positive ET observed for a median time of 9\u00a0years. We examined blood count of each patient at the time of diagnosis and confronted it with 2008 and 2016 WHO criteria for PV and mPV. Additionally, we analyzed <jats:italic>JAK2V617F<\/jats:italic> allele burden in two separate time points among selected cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Confrontation with new criteria resulted in change of diagnosis to PV and mPV in 10% and 9% cases, respectively. Within remaining patients, 14 showed increasing hemoglobin concentration over several months during late course of disease, resulting in change of diagnosis to overt PV. We did not find suggested increase in <jats:italic>JAK2<\/jats:italic> allele burden among transforming patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Phenotype transformation to polycythemia was proven to be possible within the group of <jats:italic>JAK2<\/jats:italic>\u2010mutated ET; however, cause of this effect remains uncertain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13320","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T16:18:49Z","timestamp":1566836329000},"page":"558-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Late polycythemic transformation in <i>JAK2<\/i>\u2010mutated essential thrombocythemia patients\u2014characteristics along with a validation of 2016 WHO criteria"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9112-5017","authenticated-orcid":false,"given":"Patryk","family":"Sobieralski","sequence":"first","affiliation":[{"name":"Department of Hematology and Transplantology Medical University of Gda\u0144sk Gda\u0144sk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Leszczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Hematology and Transplantology Medical University of Gda\u0144sk Gda\u0144sk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5704-0244","authenticated-orcid":false,"given":"Maria","family":"Bieniaszewska","sequence":"additional","affiliation":[{"name":"Department of Hematology and Transplantology Medical University of Gda\u0144sk Gda\u0144sk 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