{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:19:20Z","timestamp":1775503160531,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Iron deficiency in polycythaemia vera (PV) may impact the validity of the haematocrit (HCT), since HCT is red blood cell count (RBC) \u00d7 mean corpuscular volume (MCV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate (a) the effect of microcytosis on HCT, (b) the erythrocyte sedimentation rate (ESR) as a possible additional diagnostic marker for PV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This study included 182 subjects: 39 with PV, 27 with essential thrombocythemia (ET) and 116 suspected of myeloproliferative neoplasm (MPN) with a secondary cause for either thrombocytosis or erythrocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with PV had significantly lower ratio of MCV and serum ferritin compared to MPN suspects. A good correlation of RBC versus HCT was found for PV and MPN subjects when individuals with microcytosis were excluded (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0.87 in PV and <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0.82 in MPN suspects). We found a specificity of 98% and a sensitivity of 37% for ESR &lt;2\u00a0mm in the diagnosis of PV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The RBC may more precisely reflect the total red cell mass and accordingly the hypercoagulable state of the PV patient, which is integrated in the ESR. A combination of RBC and ESR is proposed as a novel tool to substitute the Hb concentration and the HCT in the diagnosis of PV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13334","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T13:40:04Z","timestamp":1570196404000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The red blood cell count and the erythrocyte sedimentation rate in the diagnosis of polycythaemia vera"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7786-9626","authenticated-orcid":false,"given":"Vardan","family":"Nersesjan","sequence":"first","affiliation":[{"name":"Department of Neurology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-1635","authenticated-orcid":false,"given":"Kristoffer A.","family":"Zervides","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Rheumatology, Lund University Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-1595","authenticated-orcid":false,"given":"Anders L.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital Roskilde Denmark"},{"name":"Institute for Inflammation Research Center for Rheumatology and Spine Diseases Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6767-0226","authenticated-orcid":false,"given":"Lasse","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-7826","authenticated-orcid":false,"given":"Vibe","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-8032","authenticated-orcid":false,"given":"Hans C.","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406186"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-009-0005-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0054-y"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05517.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-508416"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.213108"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05535.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06741.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15648"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.380"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1970.28.6.775"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-128454"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0349"},{"issue":"4","key":"e_1_2_6_16_1","first-page":"443","article-title":"The bone marrow in polycythemia vera","volume":"12","author":"Ellis B","year":"1975","journal-title":"Semin Hematol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0207-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/era.11.10"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.966243"},{"issue":"4","key":"e_1_2_6_20_1","first-page":"1","article-title":"The erythrocyte count on top of bone marrow histology discriminates essential thrombocythemia and polycythemia vera in JAK2V617F mutated prefibrotic myeloproliferative neoplasm with no or minor splenomegaly","volume":"2","author":"Michiels JJ","year":"2014","journal-title":"J Hematol Thromboembolic Dis"},{"issue":"5","key":"e_1_2_6_21_1","first-page":"1443","article-title":"Clinical utility of the erythrocyte sedimentation rate","volume":"60","author":"Brigden ML","year":"1999","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2013.02.019"},{"issue":"3","key":"e_1_2_6_23_1","first-page":"IV1","article-title":"Guidelines for the management of iron deficiency anaemia","volume":"46","author":"Goddard AF","year":"2000","journal-title":"Gut"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208500"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.008417"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92098-6"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90179-9"},{"issue":"5","key":"e_1_2_6_28_1","first-page":"200","article-title":"Cerebral blood flow in polycythaemia vera","volume":"15","author":"Lahtinen R","year":"1983","journal-title":"Ann Clin Res"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996120"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018834044"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.210732"},{"key":"e_1_2_6_32_1","first-page":"1","article-title":"Arterial and venous thrombosis by high platelet count and high hematocrit: 108,521 individuals from the Copenhagen general population study","author":"Warny M","year":"2019","journal-title":"J Thromb Haemost"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13047"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.163"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23585"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.12.69"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12552"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.11.63"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.90"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"issue":"10","key":"e_1_2_6_41_1","first-page":"1194","article-title":"Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis","volume":"89","author":"Mossuz P","year":"2004","journal-title":"Blood"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.13334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T16:03:22Z","timestamp":1693843402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.13334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/ejh.13334"],"URL":"https:\/\/doi.org\/10.1111\/ejh.13334","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,22]]},"assertion":[{"value":"2019-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}