{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:20:57Z","timestamp":1784305257248,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The prognostic value of site of nodal involvement in diffuse large B\u2010cell lymphomas (DLBCL) is mainly unknown. We aimed to determine the prognostic significance of nodal abdominal involvement in relation to tumour cell markers and clinical characteristics of 249 DLBCL patients in a retrospective single\u2010centre study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Contrast\u2010enhanced computed tomography (CT) of the abdomen and thorax revealed pathologically enlarged abdominal lymph nodes in 156 patients, while in 93 patients there were no pathologically enlarged lymph nodes in the abdomen. In 81 cases, the diagnosis of DLBCL was verified by histopathological biopsy obtained from abdominal lymph node.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with abdominal nodal disease had inferior lymphoma\u2010specific survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) and presented with higher age\u2010adjusted IPI (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), lactate dehydrogenase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and more often advanced stage (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), bulky disease (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), B symptoms (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and double expression of MYC and BCL2 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) compared to patients without nodal abdominal involvement, but less often extranodal involvement (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.02). The worst outcome was observed in those where the abdominal nodal involvement was verified by histopathological biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diffuse large B\u2010cell lymphomas patients with abdominal nodal disease had inferior outcome and more aggressive behaviour, reflected both in clinical and biological characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13361","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:10:06Z","timestamp":1575281406000},"page":"207-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic impact of abdominal lymph node involvement in diffuse large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-0656","authenticated-orcid":false,"given":"Maysaa","family":"Abdulla","sequence":"first","affiliation":[{"name":"Clinical and Experimental Pathology Department of Immunology, Genetics and Pathology Uppsala University and University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Guglielmo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Radiology Uppsala University and University Hospital Uppsala Sweden"},{"name":"Brotzu General Hospital Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-5681","authenticated-orcid":false,"given":"Peter","family":"Hollander","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Pathology Department of Immunology, Genetics and Pathology Uppsala University and University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"\u00c5str\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Radiology Uppsala University and University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Ahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Radiology Uppsala University and University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Enblad","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-5252","authenticated-orcid":false,"given":"Rose\u2010Marie","family":"Amini","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Pathology Department of Immunology, Genetics and Pathology Uppsala University and University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2018.08.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.11.030"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.7192"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1997.tb00956.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0113"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.83"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHMZ6VHF0WQV"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.4342"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-101899"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.4505"},{"key":"e_1_2_6_16_1","unstructured":"NetworkNCC.National Comprehensive Cancer Network (NCCN) Guidelines B\u2010Cell Lymphoma.2018February 26 2018 [cited; 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