{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:48:16Z","timestamp":1758635296368,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A treatment regimen consisting of bendamustine and brentuximab vedotin (BV) has been described as a highly potent salvage therapy and as an effective induction therapy leading to high response rates before autologous stem cell transplantation (ASCT) in patients with classical Hodgkin lymphoma (cHL). In this retrospective analysis, we aimed to assess this therapy's efficacy in unselected patients with cHL and CD30+ peripheral T\u2010cell lymphoma (PTCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Data of 28 patients with cHL and five patients with PTCL treated with a combination of bendamustine and BV at three Austrian tertiary cancer centers were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with cHL, the ORR was 100% (78.6% CR, 21.4% PR). After 17\u00a0months median follow\u2010up, median survival times were not reached; 1\u2010year PFS was 81.9%, and 1\u2010year OS was 95.7%. Thirteen eligible patients (46.4%) successfully underwent planned ASCT after salvage therapy with bendamustine and BV and subsequent high\u2010dose chemotherapy. Three of the five PTCL patients achieved CR, while two did not respond and died during or shortly after therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A combination of bendamustine and BV is an effective salvage and induction therapy before ASCT in patients with relapsed\/refractory cHL. Further research is warranted to evaluate the use in patients with PTCL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13368","type":"journal-article","created":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T09:55:02Z","timestamp":1576403702000},"page":"251-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Treatment with brentuximab vedotin plus bendamustine in unselected patients with CD30\u2010positive aggressive lymphomas"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0788-3630","authenticated-orcid":false,"given":"Sandro M.","family":"Wagner","sequence":"first","affiliation":[{"name":"3rd Medical Department with Hematology and Medical Oncology Paracelsus Medical University Salzburg Salzburg Austria"},{"name":"Salzburg Cancer Research Institute\u2010CCCIT Salzburg 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