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This study aims to assess high\u2010dose cyclophosphamide to treat relapsed or refractory lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A phase II study included adult patients with relapsed or refractory B\u2010cell non\u2010Hodgkin's lymphoma, previously treated by \u22652 prior lines with no other available option of therapy. High\u2010dose cyclophosphamide was given intravenously 3\u00a0g\/m<jats:sup>2<\/jats:sup> over two consecutive days and repeated once at 28\u00a0days in responding patients. Rituximab 375\u00a0mg\/m<jats:sup>2<\/jats:sup> intravenously was added in patients not refractory to anti\u2010CD20 antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two patients with median age 65 [56\u201070] years were included. Patients had previously received a median of four lines of therapies. Tumor types were diffuse large B\u2010cell lymphoma (n\u00a0=\u00a026; 62%), indolent B\u2010cell non\u2010Hodgkin lymphoma (n\u00a0=\u00a010; 24%), or mantle lymphoma (n\u00a0=\u00a06; 14%). Hematologic and non\u2010hematologic grade 3\u20105 toxicities occurred in 42 (100%) and 18 (43%) of patients, respectively. The overall response rate was 45%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One to two cycles of high\u2010dose cyclophosphamide in hard\u2010to\u2010treat patients with relapsed or refractory B\u2010cell non\u2010Hodgkin lymphoma demonstrated a favorable safety and efficacy profile. This regimen could serve as a bridge to modern cellular therapy with CAR\u2010T cell.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13369","type":"journal-article","created":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T07:24:36Z","timestamp":1576394676000},"page":"281-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High\u2010dose cyclophosphamide for hard\u2010to\u2010treat patients with relapsed or refractory B\u2010cell non\u2010Hodgkin's lymphoma, a phase II result"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3482-3331","authenticated-orcid":false,"given":"Jean\u2010Marie","family":"Michot","sequence":"first","affiliation":[{"name":"D\u00e9partement des Innovations Th\u00e9rapeutiques et Essais Pr\u00e9coces Gustave Roussy Universit\u00e9 Paris\u2010Saclay Villejuif France"},{"name":"D\u00e9partement d'H\u00e9matologie Gustave Roussy Universit\u00e9 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