{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:24:26Z","timestamp":1789176266755,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eltrombopag is useful for immune thrombocytopenia (ITP). However, results of clinical trials may not accurately mirror clinical practice reality. Here we evaluated eltrombopag for primary and secondary ITP in our \u226565\u2010year\u2010old population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 106 primary ITP patients (16 with newly diagnosed ITP, 16 with persistent ITP, and 74 with chronic ITP) and 39 secondary ITP patients (20 with ITP secondary to immune disorders, 7 with ITP secondary to infectious diseases, and 12 with ITP secondary to lymphoproliferative disorders [LPD]) were retrospectively evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age of our cohort was 76 (interquartile range, IQR, 70\u201081)\u00a0years. 75.9% of patients yielded a platelet response including 66.2% complete responders. Median time to platelet response was 14 (IQR, 8\u201021)\u00a0days. Median time on response was 320 (IQR, 147\u2010526)\u00a0days. Sixty\u2010three adverse events (AEs), mainly grade 1\u20102, occurred. The most common were hepatobiliary laboratory abnormalities (HBLAs) and headaches. One transient ischemic attack in a newly diagnosed ITP and two self\u2010limited pulmonary embolisms in secondary ITP were the only thrombotic events observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Eltrombopag showed efficacy and safety in ITP patients aged \u226565\u00a0years with primary and secondary ITP. However, efficacy results in LPD\u2010ITP were poor. A relatively high number of deaths were observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13370","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T08:16:13Z","timestamp":1576484173000},"page":"259-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Use of eltrombopag for patients 65\u00a0years old or older with immune thrombocytopenia"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-1816","authenticated-orcid":false,"given":"Tom\u00e1s Jos\u00e9","family":"Gonz\u00e1lez\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital Universitario de Burgos Burgos Spain"},{"name":"Department of Health Sciences University of Burgos Burgos 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