{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:22:26Z","timestamp":1788960146778,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Survival outcomes from a single\u2010arm phase 2 blinatumomab study in patients with minimal residual disease (MRD)\u2010positive B\u2010cell precursor (BCP)\u2010acute lymphoblastic leukaemia (ALL) were compared with those receiving standard of care (SOC) in a historic data set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The primary analysis comprised adult Philadelphia chromosome (Ph)\u2010negative patients in first complete haematologic remission (MRD\u00a0\u2265\u00a010<jats:sup>\u22123<\/jats:sup>). Relapse\u2010free survival (RFS) and overall survival (OS) were compared between blinatumomab\u2010 and SOC\u2010treatment groups. Baseline differences between groups were adjusted by propensity scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary analysis included 73 and 182 patients from the blinatumomab and historic data sets, respectively. When weighted by age to the blinatumomab\u2010treatment group, median RFS was 7.8\u00a0months and median OS was 25.9\u00a0months in the SOC\u2010treated group. In the blinatumomab study, median RFS was 35.2\u00a0months; median OS was not evaluable. Propensity score weighting achieved balance with seven baseline prognostic factors. With adjustment for haematopoietic stem cell transplantation (HSCT) status, a 50% reduction in risk of relapse or death was observed with blinatumomab vs SOC. Median RFS, unadjusted for HSCT status, was 35.2\u00a0months with blinatumomab and 8.3\u00a0months with SOC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These analyses suggest that blinatumomab improves RFS, and possibly OS, in adults with MRD\u2010positive Ph\u2010negative BCP\u2010ALL vs SOC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13375","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T06:54:58Z","timestamp":1577343298000},"page":"299-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Blinatumomab vs historic standard\u2010of\u2010care treatment for minimal residual disease in adults with B\u2010cell precursor acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2291-8245","authenticated-orcid":false,"given":"Nicola","family":"G\u00f6kbuget","sequence":"first","affiliation":[{"name":"University Hospital Goethe University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Dombret","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint\u2010Louis University Paris Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Giebel","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie Institute\u2014Oncology Center Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Doubek","sequence":"additional","affiliation":[{"name":"University Hospital and CEITEC Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Foa","sequence":"additional","affiliation":[{"name":"\u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Hoelzer","sequence":"additional","affiliation":[{"name":"J.W. 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