{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:53:03Z","timestamp":1761897183188,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We herein report the case of a 73\u2010year\u2010old male patient who was diagnosed with leukemic non\u2010nodal MCL. This patient had received six cycles of bendamustine, which resulted in a transient remission, and a second\u2010line therapy with ibrutinib, which unfortunately failed to induce remission. We started a treatment with single\u2010agent obinutuzumab at a dose of 20\u00a0mg on day 1, 50\u00a0mg on day 2\u20104, 330\u00a0mg on day 5, and 1000\u00a0mg on day 6. The laboratory analysis showed a rapid decrease of leukocyte count. Four weeks later, we repeated the treatment with obinutuzumab at a dose of 1000\u00a0mg q4w and started a therapy with venetoclax at a dose of 400\u00a0mg\u00a0qd, which could be increased to 800\u00a0mg\u00a0qd from the third cycle. This combination therapy was well tolerated. The patient achieved a complete remission (CR) after three cycles of obinutuzumab and venetoclax. To date, the patient has a progression\u2010free survival of 17\u00a0months under ongoing obinutuzumab maintenance q4w. This is the first report about obinutuzumab and venetoclax induced CR in rituximab\u2010intolerant patient with an ibrutinib\u2010resistant MCL. This case suggests that obinutuzumab\u2010 and venetoclax\u2010based combination therapy might be salvage therapy in patients with ibrutinib\u2010resistant MCL.<\/jats:p>","DOI":"10.1111\/ejh.13382","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T12:52:35Z","timestamp":1578660755000},"page":"352-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Obinutuzumab and venetoclax induced complete remission in a patient with ibrutinib\u2010resistant non\u2010nodal leukemic mantle cell lymphoma"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-0919","authenticated-orcid":false,"given":"Xiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian Johannes","family":"Steinhardt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"D\u00fcll","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Krummenast","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Danhof","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Meckel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Nickel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Grathwohl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Benno","family":"Leicht","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II W\u00fcrzburg University 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