{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:14:22Z","timestamp":1791389662183,"version":"4.3.3"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T00:00:00Z","timestamp":1582329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous epidemiological studies suggest an association between hepatitis B virus (HBV) infection and B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL). The aim of our study was to evaluate clinical characteristics and serological indicators of HBV activity in patients who were diagnosed with both HBV infection and indolent or aggressive B\u2010NHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010two patients with current or resolved HBV infection and B\u2010NHL were identified between 2000 and 2017 at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five (63%) and 27 (37%) patients were identified with aggressive and indolent B\u2010NHL, respectively. In indolent B\u2010NHL, the proportion of HBsAg\u2010positive patients was significantly higher compared with aggressive B\u2010NHL (59% vs 38%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). HBV\u2010DNA levels were significantly higher in patients with indolent compared to aggressive B\u2010NHL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). In the subgroup analyzes of follicular lymphoma (FL) and diffuse large B\u2010cell lymphoma (DLBCL), the rate of HBsAg positivity in FL is significantly higher than that in DLBCL (83% vs 44%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04), and HBV\u2010DNA levels were significantly higher in FL compared with DLBCL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that serological HBV activity is higher in patients with both HBV infection and indolent B\u2010NHL compared to those with aggressive B\u2010NHL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13388","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T11:50:10Z","timestamp":1579607410000},"page":"469-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Serological hepatitis B virus (HBV) activity in patients with HBV infection and B\u2010cell non\u2010Hodgkin\u2019s lymphoma"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-0919","authenticated-orcid":false,"given":"Xiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital University of Heidelberg Heidelberg Germany"},{"name":"Department of Internal Medicine II W\u00fcrzburg University Hospital University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9482-2870","authenticated-orcid":false,"given":"Patrick","family":"Wuchter","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine and Immunology Medical Faculty Mannheim Heidelberg University German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2014Hessen Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlinde","family":"Egerer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kriegsmann","sequence":"additional","affiliation":[{"name":"Insititue of Pathology Heidelberg University Hospital University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix K. 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