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Bv was given at 1.8\u00a0mg\/kg on day 1 and bendamustine at 90\u00a0mg\/m<jats:sup>2<\/jats:sup> on days 1 and 2 of a 21\u2010day cycle. The median number of BvB cycles was 4 (2\u20107), and all patients were evaluable for efficacy. The CR and OR rates were 49% and 79%, respectively; 67% of responding patients and 2 in stable disease proceeded to a SCT procedure. After a median follow\u2010up of 19\u00a0months (5\u201047), median PFS was 18\u00a0months (95%CI: 23\u201029), and the 2\u2010year OS was 72%. Significantly longer PFS and OS were observed in patients attaining a major clinical response to treatment and in those who received consolidation with SCT. Fifteen (32%) patients experienced severe (G\u00a0&gt;\u00a02) toxicity. The main toxicities were neutropenia (23%), gastrointestinal (10%), peripheral sensory neuropathy (11%), and infection (4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our real\u2010world results suggest that BvB is an effective third\u2010line rescue and bridge\u2010to\u2010transplant regimen for RR\u2010cHL patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13400","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T17:25:11Z","timestamp":1582824311000},"page":"581-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Brentuximab vedotin in association with bendamustine in refractory or multiple relapsed Hodgkin lymphoma. 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