{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:11:18Z","timestamp":1759482678674,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The R\u2010DHAP regimen (rituximab, cisplatin, dexamethasone, and high\u2010dose cytarabine) is standardly used to treat relapsed Non\u2010Hodgkin lymphoma (NHL). Despite scarce data, cisplatin is frequently substituted with oxaliplatin (R\u2010DHAOx) to avoid nephrotoxicity. We compared nephrotoxicity of cisplatin and oxaliplatin based on creatinine\u2010based trajectory modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with NHL treated by R\u2010DHAP or R\u2010DHAOx in Angers hospital between January 01, 2007, and December 31, 2014, were included. Patients received cisplatin 100\u00a0mg\/m<jats:sup>2<\/jats:sup> or oxaliplatin 130\u00a0mg\/m<jats:sup>2<\/jats:sup> (d1) with cytarabine (2000\u00a0mg\/m<jats:sup>2<\/jats:sup>, two doses, d2), dexamethasone (40\u00a0mg, d1\u20104), and rituximab (375\u00a0mg\/m<jats:sup>2<\/jats:sup>, d1). Creatinine levels were recorded before each cycle. Individual profiles of trajectories were clustered to detect homogeneous patterns of evolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two patients received R\u2010DHAP, 35 R\u2010DHAOx, 6 switched from R\u2010DHAP to R\u2010DHAOx due to nephrotoxicity. Characteristics of patients were similar between two groups. Patients receiving R\u2010DHAP experienced more severe renal injury than patients receiving R\u2010DHAOx (68% vs. 7.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Two homogeneous clusters appeared: cluster A, with a majority of R\u2010DHAOx (32, 91.4%), was less nephrotoxic than B, with a majority of R\u2010DHAP (19, 86.4%), with a decreased average serum creatinine level (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). There were no other differences between clusters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study confirms that R\u2010DHAOx regimen causes less nephrotoxicity than R\u2010DHAP regimen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13429","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T19:41:23Z","timestamp":1587152483000},"page":"223-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["R\u2010DHA\u2010oxaliplatin (R\u2010DHAOx) versus R\u2010DHA\u2010cisplatin (R\u2010DHAP) regimen in B\u2010cell lymphoma treatment: A eight\u2010year trajectory study"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2875-6048","authenticated-orcid":false,"given":"Carole","family":"Lacout","sequence":"first","affiliation":[{"name":"Service des Maladies du Sang CHU Angers Angers 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