{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:01:38Z","timestamp":1747184498501,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We report an extension study of patients with essential thrombocythaemia (ET) in the Hungarian Myeloproliferative Neoplasm (HUMYPRON) Registry, which demonstrated that over 6\u00a0years anagrelide significantly decreased the number of patients experiencing minor arterial and minor venous thrombotic events (TEs) vs hydroxyurea+aspirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on patients with ET were collected through completion of a questionnaire developed according to 2008 WHO diagnostic criteria and with regard to Landolfi, Tefferi and IPSET criteria for thrombotic risk. Data were entered into the registry from 14 haematological centres. TEs, secondary malignancies, disease progression and survival were compared between patients with ET treated with anagrelide (n\u00a0=\u00a0116) and with hydroxyurea+aspirin (n\u00a0=\u00a0121).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were followed for (median) 10\u00a0years. A between\u2010group difference in the number of patients with TEs was observed (25.9% anagrelide vs 38.0% hydroxyurea+aspirin; <jats:italic>P\u00a0<\/jats:italic>=\u00a0.052). Minor arterial events were more frequently reported in the hydroxyurea+aspirin group (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.001); there were marginally more reports of major arterial events in the anagrelide group (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.049). TE prior to diagnosis was found to significantly influence TE incidence (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a0.001). Progression\u2010free survival (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.004) and survival (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.001) were significantly increased for the anagrelide group vs hydroxyurea+aspirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anagrelide reduced TEs, and increased progression\u2010free and overall survival vs hydroxyurea+aspirin over (median) 10\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13459","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T08:56:26Z","timestamp":1591260986000},"page":"408-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anagrelide influences thrombotic risk, and prolongs progression\u2010free and overall survival in essential thrombocythaemia vs hydroxyurea plus aspirin"],"prefix":"10.1111","volume":"105","author":[{"given":"Adam","family":"Kellner","sequence":"first","affiliation":[{"name":"Department of Haematology Somogy County Kaposi Mor Teaching Hospital Kaposv\u00e1r Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Dombi","sequence":"additional","affiliation":[{"name":"Szent Borbala County Hospital Tatab\u00e1nya Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpad","family":"Illes","sequence":"additional","affiliation":[{"name":"Department of Haematology Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Demeter","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Division of Haematology Semmelweis University of Budapest Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Homor","sequence":"additional","affiliation":[{"name":"Faculty of Humanities and Social Sciences Pazmany Peter Catholic University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibolya","family":"Ercsei","sequence":"additional","affiliation":[{"name":"Department of Haematology Somogy County Kaposi Mor Teaching Hospital Kaposv\u00e1r Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsofia","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Haematology Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Karadi","sequence":"additional","affiliation":[{"name":"Department of Haematology Somogy County Kaposi Mor Teaching Hospital Kaposv\u00e1r Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozsef","family":"Herczeg","sequence":"additional","affiliation":[{"name":"Department of Haematology Somogy County Kaposi Mor Teaching Hospital Kaposv\u00e1r Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Gy Korom","sequence":"additional","affiliation":[{"name":"Department of Haematology Somogy County Kaposi Mor Teaching Hospital Kaposv\u00e1r Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Gasztonyi","sequence":"additional","affiliation":[{"name":"Karolina General Hospital Mosonmagyarovar Mosonmagyarovar Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Szerafin","sequence":"additional","affiliation":[{"name":"Josa Andras Teaching Hospital Nyiregyhaza Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miklos","family":"Udvardy","sequence":"additional","affiliation":[{"name":"Department of Haematology Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5513-5880","authenticated-orcid":false,"given":"Miklos","family":"Egyed","sequence":"additional","affiliation":[{"name":"Department of Haematology Somogy County Kaposi Mor Teaching Hospital Kaposv\u00e1r Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-304"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-696005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24221"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"95","article-title":"Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk\u2010stratification, and management","volume":"92","author":"Teffari A","year":"2017","journal-title":"Am J Hematol"},{"issue":"10","key":"e_1_2_9_7_1","first-page":"773","article-title":"Current challenges in the management of essential thrombocythemia","volume":"15","author":"Kleman A","year":"2017","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.06.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.95"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-579136"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.113"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.5298"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.06.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-339002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12806"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1556\/650.2016.30340"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209262"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12604"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-444067"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.94"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-695957"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-403279"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-443770"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20646"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043800"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(88)90054-8"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996108"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1218-2"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.05.014"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4999\/uhod.193371"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845412Y.0000000023"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13156"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2019.02.004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.7542"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.1925"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24882"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.13459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.13459","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T18:32:36Z","timestamp":1693938756000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.13459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/ejh.13459"],"URL":"https:\/\/doi.org\/10.1111\/ejh.13459","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"type":"print","value":"0902-4441"},{"type":"electronic","value":"1600-0609"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}