{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:04:07Z","timestamp":1784865847066,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Although phase 2 studies have confirmed the efficacy of mogamulizumab for adult T\u2010cell leukemia\/lymphoma (ATL), real\u2010world data on its benefits are limited. We assessed the benefits of mogamulizumab for relapsed\/refractory ATL in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed patients with acute\u2010 and lymphoma\u2010type ATL. Among 57 patients diagnosed with ATL between January 2008 and August 2018, 42 who received salvage therapy were eligible, including 24 who received mogamulizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall response rate to mogamulizumab was 54.2%. Median survival time (MST) and 1\u2010year overall survival (OS) rate from mogamulizumab initiation were 7.7\u00a0months and 42.0%, respectively. Patients with acute\u2010type ATL showed longer MST (15.1\u00a0months) and higher 1\u2010year OS (63.6%). MST without skin rash was 5.0\u00a0months, and 1\u2010year OS was 34.3%; however, MST with skin rash was not reached and 1\u2010year OS was 66.7%. Among patients who received the salvage therapy, longer MST and higher 1\u2010year OS were observed with mogamulizumab than without mogamulizumab (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.078; 9.2 vs. 3.9\u00a0months; 47.9% vs. 17.6%, respectively). Mogamulizumab administration improved prognosis in patients with acute\u2010type ATL and skin rash.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In clinical practice, mogamulizumab improved OS in patients with relapsed\/refractory ATL, especially those with acute\u2010type ATL and skin rash.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13474","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T10:35:45Z","timestamp":1592735745000},"page":"704-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical efficacy of mogamulizumab for relapsed\/refractory aggressive adult T\u2010cell leukemia\/lymphoma: A retrospective analysis"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-6264","authenticated-orcid":false,"given":"Atsushi","family":"Satake","sequence":"first","affiliation":[{"name":"First Department of 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