{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:01:18Z","timestamp":1789056078997,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Further data are needed on the safety of high\u2010dose melphalan and autologous stem cell transplant (HDM\u2010ASCT) in patients with multiple myeloma (MM) and renal impairment. The objective of our study was to use the National Inpatient Sample (NIS) to determine inpatient mortality for patients with MM and renal impairment undergoing HDM\u2010ASCT, as well as trends over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the NIS, we tracked hospital admissions for MM patients from 2002 to 2014 who underwent HDM\u2010ASCT, using ICD 9 coding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total weighted estimate of inpatient admissions for HDM\u2010ASCT among MM patients was 47,253 from 2002 to 2014. A weighted total of 45 and 1709 patients with MM received peritoneal dialysis (PD) and hemodialysis (HD) during HDM\u2010ASCT for MM, respectively. There was a markedly increased risk of inpatient mortality in patients on dialysis undergoing transplant (20.5% for PD patients, 13.8% for HD patients), even after accounting for other comorbidities (odds ratio of inpatient mortality of 6.193 [CI 3.585\u201010.701]). A significant decrease was noted in inpatient mortality for patients with ESRD undergoing HDM\u2010ASCT over time from 15.6% in 2009 to 5% in 2014 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with MM on dialysis undergoing HDM\u2010ASCT are at significantly increased risk of inpatient mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13487","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T08:55:04Z","timestamp":1594716904000},"page":"571-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inpatient mortality of patients with multiple myeloma and renal impairment undergoing autologous stem cell transplantation"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6464-783X","authenticated-orcid":false,"given":"Ghulam Rehman","family":"Mohyuddin","sequence":"first","affiliation":[{"name":"University of Kansas Cancer Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqib","family":"Abbasi","sequence":"additional","affiliation":[{"name":"University of Kansas Cancer Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maire","family":"Okoniewski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kansas Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"McClune","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies Department of Internal Medicine University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u2010Ola","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Hematological Malignancies and Cellular Therapeutics University of Kansas Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Hematological Malignancies and Cellular Therapeutics University of Kansas Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"McGuirk","sequence":"additional","affiliation":[{"name":"Department of Hematological Malignancies and Cellular Therapeutics University of Kansas Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Shune","sequence":"additional","affiliation":[{"name":"Department of Hematological Malignancies and Cellular Therapeutics University of Kansas Kansas City KS 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