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Skeletal involvement is typically associated with high tumor burden and bone marrow infiltration. However, isolated cases of skeletal disease without splenomegaly or bone marrow involvement are occasionally reported. This review focuses on skeletal lesions in HCL, particularly the pathogenesis, clinical symptoms, diagnostic methods, and treatment approach. A literature review of the MEDLINE database for articles in English concerning hairy cell leukemia, skeletal symptoms, bone involvement was conducted via PubMed. Publications from January 1970 to May 2020 were scrutinized. Additional relevant publications were obtained by reviewing the references from the chosen articles.<\/jats:p>","DOI":"10.1111\/ejh.13505","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T22:49:19Z","timestamp":1596667759000},"page":"682-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Bone lesions in hairy cell leukemia: Diagnosis and treatment"],"prefix":"10.1111","volume":"105","author":[{"given":"Pawel","family":"Robak","sequence":"first","affiliation":[{"name":"Department of Experimental Hematology Medical University of Lodz and Copernicus Memorial Hospital Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9319-9570","authenticated-orcid":false,"given":"Dorota","family":"Jesionek\u2010Kupnicka","sequence":"additional","affiliation":[{"name":"Department of Pathology Chair of Oncology Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kupnicki","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging Medical University of Lodz Lodz Poland"},{"name":"Copernicus Memorial Hospital Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Polliack","sequence":"additional","affiliation":[{"name":"Department of Hematology Hadassah \u2010 Hebrew University Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-4145","authenticated-orcid":false,"given":"Tadeusz","family":"Robak","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical University of Lodz and Copernicus Memorial Hospital Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25653"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21357"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv200"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-689422"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014209"},{"key":"e_1_2_8_7_1","first-page":"288","article-title":"Unusual presentations and complications of hairy cell leukemia","volume":"1","author":"Bouroncle BA","year":"1987","journal-title":"Leukemia"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.565395"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-0734.2002.00304.x"},{"key":"e_1_2_8_10_1","first-page":"2253","article-title":"Lesions osseuses au cours des leucemies a tricholeucocytes","volume":"8","author":"Weh HJ","year":"1979","journal-title":"Nouv Presse Med"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.8.1280"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20785"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840601)53:11<2401::AID-CNCR2820531106>3.0.CO;2-R"},{"key":"e_1_2_8_14_1","first-page":"237","article-title":"Hairy cell leukemia: historical aspects and bone involvement. 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