{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:39:47Z","timestamp":1773196787699,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2017\/513"],"award-info":[{"award-number":["CAN 2017\/513"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate concordance in survival time among first\u2010degree relatives with lymphoid malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By linkage of national Swedish registers, we identified 66\u00a0430 patients diagnosed with a lymphoid malignancy 1958\u20102016 with information on first\u2010degree relationships and follow\u2010up until 2017. Among these, we identified pairs of first\u2010degree relatives with any (N\u00a0=\u00a03326) or a similar (N\u00a0=\u00a0690) lymphoid malignancy subtype. We defined survival in the first\u2010degree relative as good, expected, or poor based on tertiles of deviance residuals from a multivariable Cox regression model. Next, we used Cox regression to estimate hazard ratios (HR) of death with 95% confidence intervals (CI) among patients, using the survival of their first\u2010degree relative as exposure and adjusting for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no concordance in survival among first\u2010degree relatives with any lymphoid malignancy (HR<jats:sub>good<\/jats:sub>\u00a0=\u00a01.00 (reference), HR<jats:sub>Expected<\/jats:sub>\u00a0=\u00a01.02, 95% CI: 0.89\u20101.17, HR<jats:sub>Poor<\/jats:sub>\u00a0=\u00a01.12, 95% CI: 0.98\u20101.27, <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0=\u00a0.08). Among first\u2010degree relatives with indolent lymphoma, including chronic lymphocytic leukemia, those with a first\u2010degree relative to an expected or poor survival had worse outcome compared to those with a first\u2010degree relative with good survival (HR<jats:sub>Expected<\/jats:sub>\u00a0=\u00a01.44, 95% CI: 0.82\u20102.53, HR<jats:sub>Poor<\/jats:sub>\u00a0=\u00a01.79, 95% CI: 1.07\u20103.00, <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results support a role of inherited factors in the outcome of indolent lymphoma, including chronic lymphocytic leukemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13510","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T21:20:13Z","timestamp":1598995213000},"page":"779-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Concordance in survival among first\u2010degree relatives diagnosed with indolent lymphoid malignancies including chronic lymphocytic leukemia"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-2912","authenticated-orcid":false,"given":"Fredrik","family":"Baecklund","sequence":"first","affiliation":[{"name":"Department of Medicine Solna Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"},{"name":"Pediatric Oncology Unit Karolinska University Hospital  Stockholm 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