{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:42:44Z","timestamp":1771598564137,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Cell counts have a significant impact on the complex mechanism of thrombosis in patients with essential thrombocythemia (ET). We recently demonstrated a considerable impact of white blood cell (WBC) counts on thrombotic risk in patients with optimized platelet counts by analysing a large anagrelide registry. In contrast, the current analysis of the registry aimed to estimate the influence of platelet counts on thrombotic risk in patients with optimized WBC counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cox regression analysis and Kaplan\u2010Meier plot were applied on all patients in the registry with optimized WBC counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By using the calculated cut\u2010off of 593\u00a0G\/L for platelets, Cox regression analysis revealed a clear influence of elevated platelet counts on the occurrence of a major thrombotic event (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). A Kaplan\u2010Meier plot revealed a markedly shorter time to a major thrombotic event for patients with platelet counts above the cut\u2010off (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data show clear impact of platelet lowering on the thrombotic risk in ET patients with normal WBC counts. Therefore, selective platelet lowering with anagrelide appears sufficient for thrombotic risk reduction in WHO\u2010diagnosed ET patients lacking leukocytosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13516","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T15:33:04Z","timestamp":1601047984000},"page":"58-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of platelets on major thrombosis in patients with a normal white blood cell count in essential thrombocythemia"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-9700","authenticated-orcid":false,"given":"Veronika","family":"Buxhofer\u2010Ausch","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I for Haematology with Stem Cell Transplantation, Haemostasis and Medical Oncology Ordensklinikum Linz Elisabethinen Linz Austria"},{"name":"Medical Faculty Johannes Kepler University Linz Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Wolf","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology Innsbruck Medical University Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Sormann","sequence":"additional","affiliation":[{"name":"Department of Haematology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Forjan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3 Hanusch Hospital Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Schimetta","sequence":"additional","affiliation":[{"name":"Department of Applied Systems Research and Statistics Johannes Kepler University Linz 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