{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:01:46Z","timestamp":1747184506448,"version":"3.40.5"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advanced systemic mastocytosis is a relatively rare entity where allogeneic stem cell transplantation can lead to the cure of the disease in selected patients. Delayed incomplete responses with graft\u2010versus\u2010mastocytosis effect were published in a few cases. In this particular patient's report, we describe the direct evidence and potency of graft\u2010versus\u2010mastocytosis effect of donor lymphocyte infusions in a patient with systemic mastocytosis with associated hematological neoplasm (SM\u2010AHN). In a 53\u2010year\u2010old female patient, an allogeneic stem cell transplantation after conventional induction treatment was performed for transformed acute myeloid leukemia (AML) during the course of polycythemia vera. After 6\u00a0years of remission period of AML and PV, the patient developed aleukemic mast cell leukemia and JAK2\u2010positive myeloproliferative neoplasm (SM\u2010AHN). We were able to achieve a sustained complete remission of SM\u2010AHN lasting for 6\u00a0years with only donor lymphocyte infusions in a status of mixed chimerism. The patient is in a good clinical condition and remission. The potent graft\u2010versus\u2010mastocytosis effect in this patient resembles the favorable effect of donor lymphocyte infusions in relapsing chronic myeloid leukemia patients after transplantation. This patient is, to our knowledge, the first case showing the proof of principle of graft\u2010versus\u2010mastocytosis effect.<\/jats:p>","DOI":"10.1111\/ejh.13528","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:30:27Z","timestamp":1601731827000},"page":"290-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Graft\u2010versus\u2010mastocytosis effect after donor lymphocyte infusion: Proof of principle"],"prefix":"10.1111","volume":"106","author":[{"given":"Hans","family":"H\u00e4gglund","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Uppsala University Uppsala Sweden"},{"name":"Section of Hematology Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9049-4654","authenticated-orcid":false,"given":"Akif 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Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"Sander","sequence":"additional","affiliation":[{"name":"Division of Pathology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Uppsala University Uppsala Sweden"},{"name":"Section of Hematology Uppsala University Hospital Uppsala Sweden"},{"name":"Department of Medicine, Immunology and Allergy Division Karolinska Institutet, and Clinical Immunology and Transfusion Medicine Karolinska University Hospital Stockholm 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