{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:04:02Z","timestamp":1782155042212,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Describe the GETH haploidentical stem cell transplantation (haplo\u2010HSCT) activity in non\u2010malignant disease (NMDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed data from children with NMDs who underwent haplo\u2010HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 2001 to December 2016, 26 pediatric patients underwent 31 haplo\u2010HSCT through ex vivo T cell\u2010depleted (TCD) graft platforms or post\u2010transplantation cyclophosphamide (PT\u2010Cy) at 7 Spanish centers. Five cases employed unmanipulated PT\u2010Cy haplo\u2010HSCT, 16 employed highly purified CD34<jats:sup>+<\/jats:sup> cells, and 10 employed ex vivo TCD grafts manipulated either with CD3<jats:sup>+<\/jats:sup>CD19<jats:sup>+<\/jats:sup> depletion, TCR\u03b1\u03b2<jats:sup>+<\/jats:sup>CD19<jats:sup>+<\/jats:sup> selection or naive CD45RA<jats:sup>+<\/jats:sup> T\u2010cell depletion. Peripheral blood stem cells were the sole source for patients following TCD haplo\u2010HSCT, and bone marrow was the source for one PT\u2010Cy haplo\u2010HSCT. The most common indications for transplantation were primary immunodeficiency disorders (PIDs), severe aplastic anemia, osteopetrosis, and thalassemia. The 1\u2010year cumulative incidence of graft failure was 27.4%. The 1\u2010year III\u2010IV acute graft\u2010versus\u2010host disease (GvHD) and 1\u2010year chronic GvHD rates were 34.6% and 16.7%, respectively. The 2\u2010year overall survival was 44.9% for PIDs, and the 2\u2010year graft\u2010versus\u2010host disease\u2010free and relapse\u2010free survival rate was 37.6% for the other NMDs. The transplantation\u2010related mortality at day 100 was 30.8%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although these results are discouraging, improvements will come if procedures are centralized in centers of expertise.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13536","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T09:40:51Z","timestamp":1603273251000},"page":"196-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Haploidentical transplantation in pediatric non\u2010malignant diseases: A retrospective analysis on behalf of the Spanish Group for Hematopoietic Transplantation (GETH)"],"prefix":"10.1111","volume":"106","author":[{"given":"Juan","family":"Torres Canizales","sequence":"first","affiliation":[{"name":"La Paz University Hospital Madrid Spain"},{"name":"La Paz Institute of Health Research IdiPAZ Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ferreras","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"},{"name":"La Paz Institute of Health Research IdiPAZ Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Pascual","sequence":"additional","affiliation":[{"name":"Hospital Carlos Haya M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-1594","authenticated-orcid":false,"given":"Laura","family":"Alonso","sequence":"additional","affiliation":[{"name":"Hospital Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-4784","authenticated-orcid":false,"given":"Alexandra","family":"Regueiro","sequence":"additional","affiliation":[{"name":"University of Santiago Clinical Hospital Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Plaza","sequence":"additional","affiliation":[{"name":"Virgen de la Arrixaca University Clinical Hospital Biomedical Research Institute of Murcia (IMIB) Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"P\u00e9rez Hurtado","sequence":"additional","affiliation":[{"name":"Hospital Virgen del Rocio Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Benito","sequence":"additional","affiliation":[{"name":"Hospital of Salamanca Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Couselo","sequence":"additional","affiliation":[{"name":"University of Santiago Clinical Hospital Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Fuster","sequence":"additional","affiliation":[{"name":"Virgen de la Arrixaca University Clinical Hospital Biomedical Research Institute of Murcia (IMIB) Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"D\u00edaz\u2010Almir\u00f3n","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bueno","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmina","family":"Mozo","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"G\u00f3mez L\u00f3pez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Autonomous University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Vicario","sequence":"additional","affiliation":[{"name":"Centro de Transfusi\u00f3n de la Comunidad de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Balas","sequence":"additional","affiliation":[{"name":"Centro de Transfusi\u00f3n de la Comunidad de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Sisinni","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"D\u00edaz de Heredia","sequence":"additional","affiliation":[{"name":"Hospital Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-9195","authenticated-orcid":false,"given":"Antonio","family":"P\u00e9rez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"},{"name":"La Paz Institute of Health Research IdiPAZ Paz University Hospital Madrid Spain"},{"name":"Faculty of Medicine Autonomous University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000179"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0607-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563817"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-019-01087-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.36"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00433"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0499-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00295"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-338822"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-264085"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00191"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.01.023"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2016.51.1.8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.02.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13868"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0598-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1423493"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.101"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.059378"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-599423"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.015"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401177"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.01.015"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-438408"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-019-02660-8"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.03.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.25"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.20"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.180"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25661"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.07.016"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2009.11.007"},{"issue":"3","key":"e_1_2_9_34_1","first-page":"389","article-title":"National institutes of health consensus development project on criteria for clinical trials in chronic graft\u2010versus\u2010host disease: I. The 2014 diagnosis and staging working group","volume":"21","author":"Jagasia MH","year":"2015","journal-title":"Report"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-609032"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.01.015"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.07.008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.240810"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21634"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy114"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","unstructured":"WahadnehAM BinDHA.Abu ShukearME et al.Mismatched Related Hematopoietic Stem Cell Transplantation in Primary Immunodeficiency.Vol 24.;2013.http:\/\/www.sjkdt.org.","DOI":"10.4103\/1319-2442.121269"},{"issue":"1","key":"e_1_2_9_43_1","first-page":"321","article-title":"Long\u2010term outcome of acquired aplastic anaemia in children: comparison between immunosuppressive therapy and bone marrow transplantation","volume":"111","author":"Kojima S","year":"2000","journal-title":"Br J Haematol"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14225"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.7"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.03.001"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.008"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","unstructured":"YueY SongZ LiJ FengS LiuR ShiX.Posttransplant Cyclophosphamide for HLA\u2010Haploidentical Transplantation in Patients With Mucopolysaccharidosis. Vol 40.;2018.www.jpho\u2010online.com.","DOI":"10.1097\/MPH.0000000000001157"},{"key":"e_1_2_9_49_1","unstructured":"KohliS RastogiN NivargiS ThakkarD KatewaS YadavSP.Successful Haploidentical Stem Cell Transplant With Posttransplant Cyclophosphamide for Hemophagocytic Lymphohistiocytosis.2018;www.jpho\u2010online.com."},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-861575"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1335"},{"key":"e_1_2_9_52_1","doi-asserted-by":"crossref","unstructured":"SchulzAS ClassenCF MihatschWA et al.HLA\u2010Haploidentical Blood Progenitor Cell Transplantation in Osteopetrosis.;2002.https:\/\/ashpublications.org\/blood\/article\u2010pdf\/99\/9\/3458\/1683008\/h80902003458.pdf.","DOI":"10.1182\/blood.V99.9.3458"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.13536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T17:06:07Z","timestamp":1693760767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.13536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/ejh.13536"],"URL":"https:\/\/doi.org\/10.1111\/ejh.13536","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"assertion":[{"value":"2020-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}