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With a median observation time of 45.9\u00a0months, the median progression\u2010free survival (PFS) and overall survival (OS) were not reached. The 36\u2010month estimated rate of PFS and OS were 64% and 68.2%, respectively. The overall response rate was noted in 23 patients (51.1%), while twenty (44.4%) patients achieved stability. Progression was noted in 2 (4.5%) cases. Analyzed molecular factors had no impact on PFS and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite accumulation of several poor prognostic factors in our real\u2010life cohort of heavily pretreated patients with CLL, ibrutinib treatment showed long\u2010term clinical benefit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13550","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T14:15:20Z","timestamp":1605449720000},"page":"320-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictive significance of selected gene mutations in relapsed and refractory chronic lymphocytic leukemia patients treated with ibrutinib"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8525-543X","authenticated-orcid":false,"given":"Marcin M.","family":"Machnicki","sequence":"first","affiliation":[{"name":"Department of Tumor 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