{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:14:37Z","timestamp":1778044477988,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective and Method<\/jats:title><jats:p>Adult T\u2010cell leukemia\/lymphoma (ATL) is an aggressive peripheral T\u2010cell lymphoma with poor prognosis. We retrospectively reviewed the medical records of 312 patients with aggressive ATL and analyzed the effect of chemotherapy dose intensity on prognosis in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>As first\u2010line therapy, 62 patients underwent best supportive care (BSC) or single\u2010agent chemotherapy, and 235 underwent intensive chemotherapy. The median survival time (MST) was 0.58\u00a0years in the 312 total patients, and 0.13\u00a0years and 0.75\u00a0years in the BSC\/single\u2010agent chemotherapy group and intensive chemotherapy group, respectively. The median average relative dose intensity (ARDI) of patients who received intensive chemotherapy was 60%. We divided patients into 3 groups according to ARDI. Those in the top tertile of ARDI (ARDI\u00a0\u2265\u00a075%, n\u00a0=\u00a082) had better overall survival compared with those in the intermediate tertile (45%\u00a0\u2264\u00a0ARDI\u00a0&lt;\u00a075%, n\u00a0=\u00a079) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), with MSTs of 4.69 and 0.75\u00a0years, respectively. The occurrence of organ dysfunction and infectious complications was comparable between the two ARDI groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher ARDI improves prognosis in patients with aggressive ATL in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13565","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T03:16:12Z","timestamp":1607656572000},"page":"398-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Higher average chemotherapy dose intensity improves prognosis in patients with aggressive adult T\u2010cell leukemia\/lymphoma"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5481-3451","authenticated-orcid":false,"given":"Masaaki","family":"Sekine","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hematology Faculty of Medicine University of 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