{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:27:09Z","timestamp":1768678029324,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The prevalence of sickle cell disease (SCD) in Spain is markedly inferior compared with other European and Mediterranean countries. However, the diagnosis of new patients with SCD is expected to increase. In this multicenter retrospective study, we analyze the hematopoietic stem cell transplantation (HSCT) results obtained in Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five patients who underwent a matched sibling donor (MSD) HSCT between 1999 and 2018 were included. Primary endpoint was event\u2010free survival (EFS), and secondary endpoints included acute and chronic graft\u2010versus\u2010host disease (GvHD) and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bone marrow was the most frequent stem cell source (93.3%). Most patients received a conditioning regimen based on busulfan and cyclophosphamide (69%). Cumulative incidence of grade III\u2010IV acute GvHD and chronic GvHD was 6.8% (95% CI: 2.3%\u201020.1%) and 5.4% (95% CI: 1.38%\u201019.9%), respectively. EFS and overall survival (OS) at 3\u00a0years post\u2010HSCT were 89.4% (95% CI: 73.9%\u201095.9%) and 92.1% (95% CI: 77.2%\u201097.4%), respectively. All patients aged\u00a0\u2264\u00a05 presented 100% EFS and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An early referral to HSCT centers should be proposed early in life, before severe complications occur. MSD HSCT should be considered a curative option for all patients aged\u00a0\u2264\u00a05\u00a0years and for older pediatric patients who present complications derived from the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13566","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T19:19:09Z","timestamp":1607627949000},"page":"408-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Matched sibling donor stem cell transplantation for sickle cell disease: Results from the Spanish group for bone marrow transplantation in children"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-8384","authenticated-orcid":false,"given":"Mar\u00eda Isabel","family":"Ben\u00edtez\u2010Carabante","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hospital Universitari Vall d\u00b4Hebron Vall d\u2019Hebron Institut de Recerca (VHIR) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bel\u00e9ndez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Gonz\u00e1lez\u2010Vicent","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-1594","authenticated-orcid":false,"given":"Laura","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hospital Universitari Vall d\u00b4Hebron Vall d\u2019Hebron Institut de Recerca (VHIR) Barcelona 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Hematology and Oncology Hospital Cl\u00ednico Universitario Virgen de la Arrixaca Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Cela","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"D\u00edaz\u2010de\u2010Heredia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hospital Universitari Vall d\u00b4Hebron Vall d\u2019Hebron Institut de Recerca (VHIR) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Grupo Espa\u00f1ol de Trasplante de M\u00e9dula \u00d3sea en Ni\u00f1os (GETMON), Grupo Espa\u00f1ol de Trasplante Hematopoy\u00e9tico 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