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However, veganism risks development of vitamin B12 deficiency as it is not available from plant sources. Moreover, its impact may be slow to be detected because body stores of vitamin B12 can last years. There is currently no published guidance on antenatal diagnosis and management of vitamin B12 deficiency. This paper reviews the metabolism, diagnosis and treatment of vitamin B12 in pregnancy. It concludes that national screening policymakers should consider introducing screening for B12 deficiency into the Antenatal and Newborn Screening Programmes for mothers and their infants if at risk of vitamin B12 deficiency. In the interim, national policy should be developed for prophylactic vitamin B12 supplementation in high\u2010risk groups around the time of pregnancy.<\/jats:p>","DOI":"10.1111\/ejh.13571","type":"journal-article","created":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T15:59:46Z","timestamp":1608479986000},"page":"450-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Review of Vitamin B12 deficiency in pregnancy: a diagnosis not to miss as veganism and vegetarianism become more prevalent"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4114-8613","authenticated-orcid":false,"given":"Sabia","family":"Rashid","sequence":"first","affiliation":[{"name":"Lewisham and Greenwich NHS Trust Queen Elizabeth Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violet","family":"Meier","sequence":"additional","affiliation":[{"name":"Library and Knowledge Services University Hospital Lewisham London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Patrick","sequence":"additional","affiliation":[{"name":"Lewisham and Greenwich NHS Trust Queen Elizabeth Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12390"},{"issue":"1","key":"e_1_2_14_3_1","first-page":"1","article-title":"Vitamin B 12 deficiency","volume":"3","author":"Green R","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/18.3.176"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S105"},{"key":"e_1_2_14_6_1","volume-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline","author":"Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes","year":"1998"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2575-6_14"},{"key":"e_1_2_14_8_1","unstructured":"https:\/\/www.evidence.nhs.uk\/search?q=vitamin+B12+in+pregnancy"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2012.01277.x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2007.tb00270.x"},{"key":"e_1_2_14_11_1","first-page":"532","article-title":"Observations on transfer of vitamin B12 from mother to fetus and newborn","volume":"96","author":"Luhby AL","year":"1958","journal-title":"Am J Dis Child"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2011.682"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0902-4441.2006.t01-1-EJH2550.x"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11636"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601236"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830480409"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2007.343"},{"key":"e_1_2_14_18_1","volume-title":"Nordic nutrition recommendations. 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