{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:32:17Z","timestamp":1791804737450,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To provide reference values for the European Organisation for Treatment and Research of Cancer (EORTC) Quality of Life Questionnaire (QLQ\u2010C30) in advanced\u2010stage Hodgkin lymphoma (HL) patients and 5\u2010year HL survivors. The QLQ\u2010C30 is the most widely used cancer\u2010specific questionnaire to assess Health\u2010Related Quality of Life (HRQoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The EORTC database was searched to identify HL RCTs in which patients\u2019 and survivors\u2019 HRQoL was assessed by the QLQ\u2010C30. HRQoL mean scores were calculated and stratified by age and gender. Minimal important differences were used to assess the clinical relevance of the findings. Data from one RCT with HRQoL scores available at baseline (n\u00a0=\u00a0343) and four RCTs with HRQoL scores available at follow\u2010up (n\u00a0=\u00a01665) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients reported worse HRQoL scores than survivors across most functioning scales and symptoms\u2019 scales. These scores varied as a function of gender but not age. Survivors\u2019 HRQoL reports were comparable to the ones of the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These values provide an assessment framework for the comparison and interpretation of QLQ\u2010C30 scores in advanced\u2010stage HL. Our findings suggest that although HL patients\u2019 HRQoL scores are worse than the general population, HRQoL scores may normalize over long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13601","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T03:03:48Z","timestamp":1613271828000},"page":"697-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Reference values for the EORTC QLQ\u2010C30 in patients with advanced stage Hodgkin lymphoma and in Hodgkin lymphoma survivors"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-649X","authenticated-orcid":false,"given":"Hugo","family":"Vachon","sequence":"first","affiliation":[{"name":"EORTC Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Mierzynska","sequence":"additional","affiliation":[{"name":"EORTC Brussels 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