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Between January 1, 2008, and December 31, 2018, 828 patients were diagnosed with DLBCL at our institution, including 72 patients who were required ICU admission during disease course. Among them, forty\u2010five patients undergoing homogeneous first\u2010line therapy with \/R\u2010CHOP\u2010like regimen and ICU\u2010admitted were selected for the present analysis. Control \u201cnon\u2010ICU\u201d DLBCL patients were matched by age, IPI score and treatment received. The median age at ICU admission was 65\u00a0years, 97.8% of patients displayed advanced\u2010stage disease (III\/IV), and 84.4% had a high IPI score (3\u20105). The main reasons for ICU admission were acute respiratory failure (40.0%) and septic shock (33.3%). The ICU mortality rate was 33.3%. The 2\u2010year PFS was lower in ICU survivors patients than in non\u2010ICU patients: 31.7% (95% CI 18.5\u201054.1) vs 60.8% (95% CI 51.2\u201072.1, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.00049). Admission to the ICU is an event that clearly impacts the outcomes of patients with DLBCL, until 2\u00a0years after the event. ICU prognosis seems mainly related to critical patient severity at admission rather than lymphoma\u2010related prognostic factors (IPIs), suggesting that ICU admission criteria should not be based only on the lymphoma prognosis.<\/jats:p>","DOI":"10.1111\/ejh.13606","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T06:35:09Z","timestamp":1614148509000},"page":"788-799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcomes after intensive care unit admission in newly diagnosed diffuse large B\u2010cell lymphoma patients: A real\u2010life study"],"prefix":"10.1111","volume":"106","author":[{"given":"Alexandra","family":"Zduniak","sequence":"first","affiliation":[{"name":"Department of Hematology Centre Henri Becquerel Rouen 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