{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:22:43Z","timestamp":1785414163879,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Pregnancies in women with polycythemia vera (PV) are associated with an increased risk of PV\u2010related maternal complications and often result in miscarriage. Recommendations for the management of PV pregnancies are mainly based on studies with a small number of patients. A correlation between pregnancy outcome and postpartum course has been reported for essential thrombocythemia, but corresponding data for PV are lacking so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 41 PV pregnancies, the pregnancy outcome, the use of PV\u2010specific therapies (ie, acetylsalicylic acid, low\u2010molecular weight heparin and\/or interferon\u2010alpha), and the postpartum PV course were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A live birth rate of 51.2% (21\/41 pregnancies) was observed. 43.9% of pregnancies ended in spontaneous abortion and 4.9% in stillbirth. A significantly increased live birth rate occurred in pregnancies with PV\u2010specific therapies compared to standard antenatal care (69.0% vs. 8.3%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0019). The use of PV\u2010specific therapy significantly increased the number of maternal hemorrhages (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.021) without increasing the risk of fetal complications. During the median postpartum follow\u2010up period of 1.2\u00a0years (range 0.1\u201013.7), complicated postpartum PV occurred significantly more often after miscarriages (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to our analysis, PV\u2010specific therapy improved the live birth rate. Significantly more complicated postpartum PV courses were observed after miscarriages.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13627","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T01:40:20Z","timestamp":1616636420000},"page":"122-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The management, outcome, and postpartum disease course of 41 pregnancies in 20 women with polycythemia vera"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-8563","authenticated-orcid":false,"given":"Kai","family":"Wille","sequence":"first","affiliation":[{"name":"University Clinic for Hematology, Oncology, Hemostaseology and Palliative Care Johannes Wesling Medical Center Minden University of Bochum Minden 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