{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:03:07Z","timestamp":1790276587718,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study, we aimed to determine the clinicopathological factors influencing the treatment\u2010free period in patients with follicular lymphoma (FL) using a watch\u2010and\u2010wait (WW) strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed histopathological parameters of 82 patients with FL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median time from diagnosis to WW discontinuation was 62\u00a0months (range, 3\u2010138), and median follow\u2010up was 86\u00a0months (range, 3\u2010183). Intermediate or high\u2010risk Follicular Lymphoma International Prognostic Index score (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.012), non\u2010duodenal\u2010type (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.011), higher numbers of interfollicular CD4<jats:sup>+<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.038) and intrafollicular FOXP3<jats:sup>+<\/jats:sup> cells (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.024) in the tumor microenvironment, and Ki\u201067 index \u226510% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.031) were significant adverse factors for WW discontinuation in univariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with adverse factors for WW discontinuation should be carefully observed during follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13637","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T18:30:30Z","timestamp":1619548230000},"page":"157-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinicopathological factors and tumor microenvironment markers predicting watch\u2010and\u2010wait discontinuation in 82 patients with follicular lymphoma"],"prefix":"10.1111","volume":"107","author":[{"given":"Sayako","family":"Yuda","sequence":"first","affiliation":[{"name":"Departments of Pathology National Cancer Center Hospital Tokyo Japan"},{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Miyagi Maeshima","sequence":"additional","affiliation":[{"name":"Departments of Pathology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Departments of Pathology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7259-4870","authenticated-orcid":false,"given":"Yuta","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Hatta","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomotaka","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Makita","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Munakata","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Izutsu","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw400"},{"key":"e_1_2_8_3_1","unstructured":"ZelenetzAD GordonLI AbramsonJS.National comprehensive cancer network guidelines. 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