{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:21:45Z","timestamp":1771503705086,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary central nervous system lymphoma (PCNSL) is a rare type of aggressive lymphoma of the central nervous system. Treatment strategies improved significantly over the past decades differ regionally but mainly consist of rituximab and high\u2010dosed methotrexate (MTX)\u2010based therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed clinical outcomes of 100 patients with newly diagnosed PCNSL between 2010\u20102020 at the University Hospital of Cologne, Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were 23\u201088\u00a0years of age and either treated with MTX\u2010based regimens (PRIMAIN, MARTA, MATRix), individual regimens, or best supportive care, respectively. Overall response rates were generally high (66,7\u201083,8%), but different organ toxicities required dose adjustments in most groups. Two\u2010year overall survival rates were 57,9% (PRIMAIN), 63,6% (MARTA), 65,4% (MATRix), and 37,5% (Other), respectively. Out of 9 patients suffering from relapse &gt;12\u00a0months from primary diagnosis, 7 patients (77,8%) received methotrexate\u2010based salvage therapy with 2\u2010year overall survival of 4\/6 patients (66,7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although a relevant proportion of patients are not eligible for clinical trials due to age, performance status, or comorbidities, these results prove feasibility of different MTX\u2010based treatment strategies in clinical routine. Even elderly patients displayed surprisingly favorable outcomes. However, with compromising organ toxicities, reduction of intensity should be part of strategies in future clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13639","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T23:55:45Z","timestamp":1620518145000},"page":"202-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment patterns and disease course of previously untreated Primary Central Nervous System Lymphoma: Feasibility of MTX\u2010based regimens in clinical routine"],"prefix":"10.1111","volume":"107","author":[{"given":"No\u00eblle","family":"Sieg","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine Faculty of Medicine and University Hospital of Cologne Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) University of Cologne Cologne Germany"},{"name":"Cologne Lymphoma Working Group Cologne 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