{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:02:03Z","timestamp":1747184523572,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Allogeneic hematopoietic cell transplantation (HCT) can be curative for acute myeloid leukemia (AML). Novel therapies may render patients\u2019 bone marrow hypocellularity and lead to prolonged post\u2010therapy pancytopenia. Patients\u2019 bone marrow cellularity (BMC) at pretransplant assessment and post\u2010treatment pancytopenia (classification CR\u2010incomplete [CRi]) may manifest AML persistence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>We retrospectively examined the impact of BMC and ELN response (ELNr) on a single\u2010center cohort of 337 patients who underwent allogeneic HCT for AML in CR1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow\u2010up was 33\u00a0months. Overall survival (OS) for the whole cohort was 55.8% at 2\u00a0years, while cumulative incidence of relapse (CIR) was 20.8%, and non\u2010relapse mortality was 27.5%. OS and CIR were not significantly different between BMC groups; and neither was ELNr. ELNr CRi was associated with BMC aplastic and hypocellular marrow states (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a02.6e\u20108). Multivariate analysis confirmed neither BMC nor attainment of ELNr CR vs CRi affected OS or relapse. Significant factors for survival included age at transplant, cytogenetic risk, development of acute Gr II\u2010IV GvHD, and moderate\u2013severe chronic GvHD, while cytogenetic risk and chronic GvHD affected relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neither ELNr status nor pretransplant BMC influenced relapse post\u2010HCT or OS. Hypocellularity and CRi are not negative prognostic factors for post\u2010HCT outcomes of AML.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13673","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T18:33:40Z","timestamp":1622658820000},"page":"354-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pretransplant bone marrow cellularity and blood count recovery are not associated with relapse or survival risk following allogeneic stem cell transplant for AML in CR"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3748-3117","authenticated-orcid":false,"given":"Igor","family":"Novitzky\u2010Basso","sequence":"first","affiliation":[{"name":"Hans Messner Allogeneic Transplant Program Princess Margaret Cancer Centre Toronto ON Canada"},{"name":"University of Toronto Toronto ON 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