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Herein, we report on 6 patients in which therapeutic embolization was combined with other medical interventions including surgery (n\u00a0=\u00a03), rituximab (n\u00a0=\u00a06), cryoablation (n\u00a0=\u00a02), and chemotherapy (n\u00a0=\u00a03). Five patients had significant tumor volume reductions (median: 83.2%; range: 76.7\u2010100). All five responding patients had resolution of symptomatology. There were no serious complications in the patients who received embolization and proceeded to surgery. In conclusion, effective disease and symptom control can be obtained in patients with symptomatic, unresectable UCD by combining different therapeutic interventions.<\/jats:p>","DOI":"10.1111\/ejh.13685","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T19:02:51Z","timestamp":1625857371000},"page":"484-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combinatorial treatment for unresectable unicentric Castleman disease"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6913-6526","authenticated-orcid":false,"given":"Meera","family":"Mohan","sequence":"first","affiliation":[{"name":"Myeloma Center University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Meek","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Elizabeth","family":"Meek","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Broadwater","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Alapat","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"van Rhee","sequence":"additional","affiliation":[{"name":"Myeloma Center University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,18]]},"reference":[{"issue":"10","key":"e_1_2_5_2_1","first-page":"396","article-title":"Case records of the Massachusetts General Hospital; weekly clinicopathological exercises; founded by Richard C. 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