{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:25:41Z","timestamp":1761294341335,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To contribute data on long\u2010term outcome and potential curative impact of ASCT in FL, especially following HDT with the BEAM protocol (BCNU, etoposide, cytarabine and melphalan), given very limited data on this topic in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Patients with FL (n\u00a0=\u00a076) were treated in our institution with HDT and ASCT. In the case of long\u2010term remission (\u22658\u00a0years), peripheral blood was tested for minimal residual disease by t(14;18)\u2010 and IGH\u2010PCR, including the last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>10\u2010year overall survival, progression\u2010free survival, and freedom from progression (FFP) after first\u2010line ASCT (n\u00a0=\u00a020) were 80%, 60%, and 69%, after second\u2010line ASCT (n\u00a0=\u00a048, following BEAM) 66%, 38%, and 41%, after third\/fourth\u2010line ASCT (n\u00a0=\u00a08) 33%, 25%, and 25%, respectively. Prognostic factors for FFP were treatment line and FLIPI (Follicular Lymphoma International Prognostic Index). 10\u2010year FFP for second\u2010line ASCT and low\u2010risk FLIPI at relapse was 69%, intermediate\u2010risk 28%, and high\u2010risk 25% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). 26 patients developed sustained long\u2010term clinical and molecular remissions of up to 27\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sustained long\u2010term clinical and molecular complete remissions up to 27\u00a0years can be achieved following ASCT (including HDT with BEAM in second treatment line), indicating a potential curative impact of ASCT in FL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13691","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T15:23:07Z","timestamp":1626794587000},"page":"543-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term outcome in patients with follicular lymphoma following high\u2010dose therapy and autologous stem cell transplantation"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1496-1377","authenticated-orcid":false,"given":"Bernd","family":"Metzner","sequence":"first","affiliation":[{"name":"Department of Oncology and Hematology Klinikum Oldenburg University Clinic Oldenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Pott","sequence":"additional","affiliation":[{"name":"Department of Medicine II University of Schleswig\u2010Holstein Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Red Cross Blood Transfusion Service NSTOB Oldenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Casper","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology Klinikum Oldenburg University Clinic Oldenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Kimmich","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology Klinikum Oldenburg University Clinic Oldenburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard K.","family":"Petershofen","sequence":"additional","affiliation":[{"name":"Red Cross Blood Transfusion Service NSTOB Oldenburg 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