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We analyzed infections' characteristics in the first month among consecutive patients with diffuse large B\u2010cell lymphoma (DLBCL) (n\u00a0=\u00a060, median age, 69.3\u00a0years), treated with commercial CAR\u2010T cells. ECOG performance status (PS) was 2\u20103 in most patients (58%). Infections were observed in 45% of patients (16, 27%, bacterial infections, and 14, 23%, viral infections). Bacterial infection included clinically documented infection in 7 (Pneumonia, n\u00a0=\u00a05; periodontal infection, n\u00a0=\u00a01; and cellulitis, n\u00a0=\u00a01) and microbiology documented infection (MDI) in 9 patients (Gram\u2010negative rod, n\u00a0=\u00a05; Gram\u2010positive cocci, n\u00a0=\u00a03, bacteremia; polymicrobial, n\u00a0=\u00a01). The most common viral infection was cytomegalovirus (CMV) reactivation (n\u00a0=\u00a010, 17%) leading to initiation of anti\u2010CMV treatment in 6 (60%) among these patients. None had CMV disease. In univariate analysis, immune effector cell\u2010associated neurotoxicity syndrome (ICANS) was associated with higher incidence of bacterial infection (OR=4.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018), while there was a trend for lower incidence of bacterial infections in patients with chemosensitive disease to bridging therapy (OR=0.375, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.074). Age or PS was not associated with increased risk of bacterial infection. Increase in C\u2010reactive protein (CRP) prior to fever onset was associated with microbiologically documented infections. We conclude that infections are common in the first month following CAR\u2010T\u2010cell administration, however, were not increased in elderly patients or those presenting with poorer PS. Increase in CRP prior to fever onset could support infection over cytokine release syndrome.<\/jats:p>","DOI":"10.1111\/ejh.13712","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T13:07:02Z","timestamp":1632661622000},"page":"52-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Characteristics and recognition of early infections in patients treated with commercial anti\u2010CD19 CAR\u2010T cells"],"prefix":"10.1111","volume":"108","author":[{"given":"Ofrat","family":"Beyar\u2010Katz","sequence":"first","affiliation":[{"name":"BMT Unit Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino","family":"Kikozashvili","sequence":"additional","affiliation":[{"name":"BMT Unit Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Sackler 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