{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:51:38Z","timestamp":1789015898039,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prognosis of patients with multiple myeloma (MM) who have relapsed on or become refractory to immunomodulators and bortezomib is poor, and treatment options are limited. While pomalidomide plus low\u2010dose dexamethasone (POM\/DEX) has demonstrated efficacy in clinical trials, real\u2010world evidence is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>POSEIDON was a prospective non\u2010interventional study designed to evaluate effectiveness, safety and quality of life (QoL) of POM\/DEX in patients with relapsed or refractory MM (R\/RMM) pretreated with at least two prior therapy lines including both lenalidomide and bortezomib in real world in Germany. Patients received POM\/DEX according to physicians\u2019 choice. Data were analyzed descriptively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2014 and 2017, 151 patients were enrolled, 144 patients with a median of three prior therapy lines qualified for effectiveness analysis. Median age was 73.2\u00a0years. Median progression\u2010free and overall survival were 6.3\u00a0months [95% confidence interval (CI) 5.2, 8.6] and 12.9\u00a0months [95% CI 10.6, 15.1]. Most frequent grade 3\/4 adverse events were leukopenia (8.2%), pneumonia (7.5%) and anemia (5.5%). QoL was maintained after start of POM\/DEX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of POSEIDON support the effectiveness and safety of POM\/DEX in R\/RMM patients pretreated with lenalidomide and bortezomib and highlight the clinical value of the POM\/DEX regimen in the real\u2010world setting.<\/jats:p><jats:p>Registered at clinicaltrials.gov (NCT02075996).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13719","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T13:08:17Z","timestamp":1635512897000},"page":"133-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pomalidomide plus dexamethasone for patients with relapsed or refractory multiple myeloma: Final results of the non\u2010interventional study POSEIDON and comparison with the pivotal phase 3 clinical trials"],"prefix":"10.1111","volume":"108","author":[{"given":"Tobias","family":"Dechow","sequence":"first","affiliation":[{"name":"Onkologie Ravensburg Ravensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aldaoud","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis f\u00fcr H\u00e4matologie &amp; Onkologie Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Behlendorf","sequence":"additional","affiliation":[{"name":"Gemeinschaftspraxis f\u00fcr Innere Medizin, H\u00e4matologie &amp; Onkologie Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Knauf","sequence":"additional","affiliation":[{"name":"Centrum f\u00fcr H\u00e4matologie und Onkologie Bethanien Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Eschenburg","sequence":"additional","affiliation":[{"name":"Internistische Gemeinschaftspraxis G\u00fcstrow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Groschek","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr H\u00e4matologie und Onkologie Stolberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hansen","sequence":"additional","affiliation":[{"name":"Schwerpunktpraxis f\u00fcr H\u00e4matologie und Onkologie Kaiserlautern Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"S\u00f6ling","sequence":"additional","affiliation":[{"name":"H\u00e4mato\u2010onkologisches Zentrum Kassel GmbH Kassel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Grebhardt","sequence":"additional","affiliation":[{"name":"iOMEDICO Freiburg im Breisgau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Ulrich","family":"Siebenbach","sequence":"additional","affiliation":[{"name":"iOMEDICO Freiburg im Breisgau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Vannier","sequence":"additional","affiliation":[{"name":"iOMEDICO Freiburg im Breisgau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Potthoff","sequence":"additional","affiliation":[{"name":"iOMEDICO Freiburg im Breisgau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201005\u2010743203"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.02.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25791"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4065\/79.7.867"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24236"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2586"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.196"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.119"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.66"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.238"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201009\u2010452375"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(13)70380\u20102"},{"key":"e_1_2_10_14_1","unstructured":"Pomalidomide alone or in combination with low\u2010dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study. 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