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Less than half of the patients develop antibody response, suggesting that they remain at risk of SARS\u2010CoV\u20102 infection even after the vaccination. Reasons for inadequate response to COVID\u201019 vaccination in chronic lymphocytic leukemia are multifactorial and attributed to disease\u2010related immune dysregulation and patient\u2010 and therapy\u2010related factors. The negative predictors of response to vaccination include hypogammaglobulinemia, advanced age, current active treatment, and past treatment anti\u2010CD20\u00a0monoclonal antibodies. Despite using booster doses and heterologous immunization to improve humoral and cellular immunity, some patients with chronic lymphocytic leukemia will fail to respond. Active treatment at the time of vaccination and a recent history of anti\u2010CD20\u00a0monoclonal antibodies use are the strongest predictors of the non\u2010response. Current data support informing patients with chronic lymphocytic leukemia and other hematologic malignancies about the risk of infection regardless of vaccination. These individuals and members of their households should continue extreme preventive actions despite relaxed local regulations. Other emerging non\u2010vaccine preventive strategies include passive and post\u2010exposure prevention with monoclonal antibodies.<\/jats:p>","DOI":"10.1111\/ejh.13722","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T18:44:13Z","timestamp":1635619453000},"page":"91-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Reasons and consequences of COVID\u201019 vaccine failure in patients with chronic lymphocytic leukemia"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6836-2903","authenticated-orcid":false,"given":"Marta","family":"Morawska","sequence":"first","affiliation":[{"name":"Experimental Hematooncology Department Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31187-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20100979\u20100"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31173-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30429-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008824"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006965"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0959-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1817"},{"key":"e_1_2_9_10_1","unstructured":"National Comprehensive Cancer Network.Recommendations of the National Comprehensive Cancer Network (NCCN) COVID\u201019 Vaccination Advisory Committee.2021.https:\/\/www.nccn.org\/covid\u201019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15247"},{"key":"e_1_2_9_12_1","unstructured":"Polish Society of Hematology and Transfusion MedicineStanowisko Polskiego Towarzystwa Hematolog\u00f3w i Transfuzjolog\u00f3w oraz Konsultanta Krajowego dotycz\u0105ce szczepie\u0144 przeciw SARS\u2010CoV\u20102 u chorych hematologicznych oraz chorych po transplantacjach kom\u00f3rek krwiotw\u00f3rczych.2021.https:\/\/ihit.waw.pl\/"},{"key":"e_1_2_9_13_1","unstructured":"ASH\u2010ASTCT COVID\u201019 Vaccination for HCT and CAR T Cell Recipients: Frequently Asked Questions. 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