{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:54:39Z","timestamp":1777892079093,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Adult T\u2010cell leukemia\u2010lymphoma (ATL) is a mature T\u2010cell lymphoproliferative neoplasm caused by human T\u2010cell leukemia virus type\u20101 infection. There is no standard treatment for relapsed or refractory (r\/r) ATL, and clinical outcomes are poor. This systematic review examined the survival outcomes for r\/r ATL treated with various systemic therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EMBASE and PubMed were searched for studies on r\/r ATL, published between January 2010 and January 2020. The main outcome of interest was overall survival (OS). Median OS and an exploratory 30% OS time were assessed based on published data and Kaplan\u2010Meier curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 21 unique treatment subgroups (from 14\u00a0studies), that met the eligibility criteria. Nine subgroups were mogamulizumab treatment, two were mogamulizumab prior to allogenic hematopoietic stem cell transplantation (allo\u2010HSCT), five were allo\u2010HSCT, and five were other chemotherapy. Respectively, the median OS and 30% OS varied considerably in range for mogamulizumab treatment (2.2\u201317.6\u00a0months and 8.7\u201327.1\u00a0months), allo\u2010HSCT (3.8\u20136.2\u00a0months and 7.5\u201319.8\u00a0months), and other chemotherapy arms (4.1\u201320.3\u00a0months and 7.1\u201317.0\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mogamulizumab was the most frequently studied treatment regimen and can potentially provide longer survival compared with chemotherapy alone. Future comparisons with synthetic or historical control arms may enable clearer insights into treatment efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13728","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T09:07:56Z","timestamp":1638608876000},"page":"212-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Systematic review of survival outcomes for relapsed or refractory adult T\u2010cell leukemia\u2010lymphoma"],"prefix":"10.1111","volume":"108","author":[{"given":"Kisato","family":"Nosaka","sequence":"first","affiliation":[{"name":"Cancer Center Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Crawford","sequence":"additional","affiliation":[{"name":"Syneos Health  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingbo","family":"Yi","sequence":"additional","affiliation":[{"name":"Syneos Health  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Kuan","sequence":"additional","affiliation":[{"name":"Syneos Health  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Syneos Health  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Medical Affairs Kyowa Kirin Co., Ltd.  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