{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:52:14Z","timestamp":1762876334818},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:00:00Z","timestamp":1641081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the Indiana Hemophilia and Thrombosis Center (IHTC) surgical database, its key components, and exploratory analyses of surgeries conducted between 1998 and 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Surgical data across bleeding disorders collected retrospectively (1998\u20132006) and prospectively (2006\u20132019) were analyzed. Perioperative hemostasis, complications, and surgical plan deviations were compared by bleeding disorder diagnosis and data collection period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within the 21\u2010year period, 3246 procedures were conducted in 1413 patients with a diagnosis of von Willebrand disease (vWD), hemophilia A (HA), hemophilia B (HB), and other bleeding disorders. Majority of the procedures were minor (63.3%), and median number of surgeries per patient was 1 (range: 1\u201322). Adequate perioperative hemostasis was achieved in 90.9%, complications occurred in 13.6%, and surgical plan deviations occurred in 31.3% of procedures. Inadequate perioperative hemostasis and surgical plan deviations occurred more frequently in procedures involving HB compared with other bleeding disorders. Complications were not significantly different across bleeding disorders (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.164). The prospective data collection period was associated with higher rates of hemostatic efficacy (92.4% vs. 88.3%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), complications (14.3% vs. 12.3%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and plan deviations (34.2% vs. 25.1%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The surgical database is an important resource in surgical management in patients with bleeding disorders. Further evaluation will facilitate use for the development of predictive models and principles of care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13731","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T13:29:33Z","timestamp":1638970173000},"page":"232-243","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Utilization of a surgical database to provide care and assess perioperative treatment and outcomes in patients with bleeding disorders"],"prefix":"10.1111","volume":"108","author":[{"given":"Omotola O.","family":"Olasupo","sequence":"first","affiliation":[{"name":"Department of Health Research Methods, Evidence &amp; Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Haddix","sequence":"additional","affiliation":[{"name":"The Indiana Hemophilia &amp; Thrombosis Center (IHTC)  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Nakar","sequence":"additional","affiliation":[{"name":"The Indiana Hemophilia &amp; Thrombosis Center (IHTC)  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Maahs","sequence":"additional","affiliation":[{"name":"The Indiana Hemophilia &amp; Thrombosis Center (IHTC)  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Greist","sequence":"additional","affiliation":[{"name":"The Indiana Hemophilia &amp; Thrombosis Center (IHTC)  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam","family":"Ghafoor","sequence":"additional","affiliation":[{"name":"The Indiana Hemophilia &amp; Thrombosis Center (IHTC)  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharyne M.","family":"Donfield","sequence":"additional","affiliation":[{"name":"Rho, Inc.  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence &amp; Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy D.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"The Indiana Hemophilia &amp; Thrombosis Center (IHTC)  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13279"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16081386"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.11.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13008"},{"key":"e_1_2_8_7_1","unstructured":"Australian Haemophilia Centre Directors\u2019 Organization (AHCDO).Guideline for the Management of Patients with Haemophilia Undergoing Surgical Procedures. November2010."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00711.x"},{"issue":"2","key":"e_1_2_8_9_1","first-page":"s45","article-title":"National and international registries of rare bleeding disorders","volume":"6","author":"Peyvandi F","year":"2008","journal-title":"Blood Transfus"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6030034"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01679.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02371.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04654.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1265-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02460.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029617715117"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118398258.ch66"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02693.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2018.08.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02329.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318041f101"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02360.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2015.50.3.173"},{"issue":"1","key":"e_1_2_8_24_1","first-page":"S48","article-title":"Electronic health records: then, now, and in the future","volume":"1","author":"Evans RS","year":"2016","journal-title":"Yearb Med Inform"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13731","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.13731","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:51:34Z","timestamp":1693212694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.13731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,2]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/ejh.13731"],"URL":"https:\/\/doi.org\/10.1111\/ejh.13731","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,2]]},"assertion":[{"value":"2021-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}