{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:04:29Z","timestamp":1772719469374,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pixantrone is a novel aza\u2010anthracenedione with antineoplastic activity, currently approved for multiply relapsed\/refractory diffuse large B\u2010cell lymphoma (DLBCL), even if real\u2010life data are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated pixantrone efficacy and safety in clinical practice, as 3<jats:sup>rd<\/jats:sup> or 4<jats:sup>th<\/jats:sup> line therapy. We retrospectively analyzed a cohort of 37 R\/R DLBCL patients managed in 8 Tuscan onco\u2010hematological centers. Pixantrone, 50\u00a0mg\/m<jats:sup>2<\/jats:sup>, was administered on days 1, 8, 15 of a 28\u00a0days cycle for up to 6 cycles. Response to therapy was evaluated according to the Lugano 2014 classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pixantrone was administered as 3<jats:sup>rd<\/jats:sup> or 4<jats:sup>th<\/jats:sup> line in 24\/37 (64.9%) and 13\/37 (35.1%) cases. Overall response rate and CR rate were 43.2% and 32.4%. After a median follow\u2010up of 6 months, 17\/37 patients (46%) were alive, the main cause of death was progressive disease (14\/37 cases, 37.9%).<\/jats:p><jats:p>Median PFS was 3\u00a0months, median DOR was 17.9\u00a0months, and median OS was 9.7 months. A significant proportion of patients achieved a long\u2010lasting response &gt;12 months (8\/37 cases). IPI&gt;2 showed a trend toward inferior PFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this real\u2010life setting, pixantrone demonstrated appreciable efficacy in a population with poor prognosis; in a small proportion of cases, it can be associated with long\u2010term remission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13745","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T18:49:35Z","timestamp":1642704575000},"page":"383-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pixantrone in patients with relapsed\/refractory diffuse large B\u2010cell lymphoma: A real\u2010life, retrospective, multicenter trial on behalf of the \u201cRTL\u201d (Regional Tuscan Lymphoma network)"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-9706","authenticated-orcid":false,"given":"Emanuele","family":"Cencini","sequence":"first","affiliation":[{"name":"Unit of Hematology Azienda Ospedaliera Universitaria Senese and University of Siena  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Mecacci","sequence":"additional","affiliation":[{"name":"Unit of Hematology Azienda Ospedaliera Universitaria Senese and University of Siena  Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melania","family":"Rocco","sequence":"additional","affiliation":[{"name":"SOC Ematologia Clinica e Oncoematologia  Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Innocenti","sequence":"additional","affiliation":[{"name":"SOC Ematologia Clinica e Oncoematologia  Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ghio","sequence":"additional","affiliation":[{"name":"Unit of Hematology Azienda Ospedaliera Universitaria Pisana and University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Puccini","sequence":"additional","affiliation":[{"name":"Lymphoma Unit Hematology Department Careggi Hospital and University of Florence  Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Della Seta","sequence":"additional","affiliation":[{"name":"Hematology Unit Ospedale di Carrara  Lido di Camaiore Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Simonetti","sequence":"additional","affiliation":[{"name":"UOC Ematologia Aziendale Ospedale Versilia  Lido di Camaiore Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Mannelli","sequence":"additional","affiliation":[{"name":"SOS Oncoematologia Ospedale S. 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